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Thromb Haemost 1974; 32(01): 057-064
DOI: 10.1055/s-0038-1647672
Original Article
Schattauer GmbH

Self-Damping Mechanism in Blood Coagulation[*]

Y Nemerson
1   Department of Internal Medicine, Yale University, New Haven, Connecticut 06510
,
S.A Silverberg
1   Department of Internal Medicine, Yale University, New Haven, Connecticut 06510
,
J Jesty
1   Department of Internal Medicine, Yale University, New Haven, Connecticut 06510
› Author Affiliations
Further Information

Publication History

Received 16 August 1974

Accepted after resubmission 16 August 1974

Publication Date:
30 June 2018 (online)

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Summary

Two reactions of the extrinsic pathway of coagulation, the activations of Factor X and prothrombin, have been studied in purified systems and shown to be self-damping. Factor X was activated by the tissue factor - Factor VII complex, and prothrombin by two systems: the coagulant protein of Taipan venom, and the physiological complex of activated Factor X, Factor V, lipid, and calcium ions. In each case the yield of enzyme, activated Factor X or thrombin, is a function of the concentration of activator. These and other observations are considered as a basis for a control mechanism in coagulation.

* Presented at the Symposium on Thrombosis, American Society of Hematology Meeting in Chicago, December 1973.


 

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