Download PDF
Thromb Haemost 1974; 32(01): 189-202
DOI: 10.1055/s-0038-1647684
Original Article
Schattauer GmbH

Effect of Induced Chronic Intravascular Coagulation on Plasminogen Activator in Dogs

Nora C. J. Sun
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota, U.S.A
,
E. J Walter Bowie
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota, U.S.A
,
Jack L. Titus
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota, U.S.A
,
Charles A. Owen Jr.
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota, U.S.A
› Author Affiliations
Further Information

Publication History

Received for publication 21 January 1974

Accepted for publication 20 May 1974

Publication Date:
30 June 2018 (online)

Also available at
    Permissions and Reprints

Summary

Plasminogen activator activity in blood vessels of various organs was determined in three untreated (control) male dogs and in two male dogs that received a continuous infusion of canine brain thromboplastic emulsion for 2 weeks. Activator was measured by the speed and degree of lysis of fibrin films that were overlaid with slices of tissue. Depletion of vascular plasminogen activator occurred in the vena cava of treated dogs at the site of the tip of the catheter, which was surrounded by a clot. A decrease of activator was found in most organs and particularly in certain endocrine organs (thyroid, pituitary, and testis). Of organs that normally contained the most activator, the greatest depletion was found in the skin, lung, and penis. The wide variation of plasminogen activator activity in organs of normal dogs is described.

 

  • References

  • 1 Albrechtsen O. K. 1957; a The fibrinolytic activity of animal tissues. Acta Physiologica Scandinavica 39: 284.
    CrossrefPubMedGoogle Scholar
  • 2 Albrechtsen O. K. 1957; b The fibrinolytic activity of human tissues. British Journal of Haematology 03: 284.
    CrossrefPubMedGoogle Scholar
  • 3 Astrup T, Albrechtsen O. K. 1957; Estimation of the plasminogen activator and the trypsin inhibitor in animal and human tissues. Scandinavian Journal of Clinical and Laboratory Investigation 09: 233.
    CrossrefPubMedGoogle Scholar
  • 4 Astrup T, Albrechtsen O. K. 1969; Serum effects following tissue thromboplastin infusion. Thrombosis et Diathesis Haemorrhagica 21: 117.
    PubMedGoogle Scholar
  • 5 Astrup T, Buluk K. 1963; Thromboplastic and fibrinolytic activities in vessels of animals. Circulation Research 13: 253.
    CrossrefPubMedGoogle Scholar
  • 6 Astrup T, Glas P, Kok P. 1970; Thromboplastic and fibrinolytic activity in lungs of some mammals. Laboratory Investigation 22: 381.
    PubMedGoogle Scholar
  • 7 Astrup T, Rasmussen J, Amery A. 1960; Fibrinolytic activity of the cirrhotic liver. Nature (London) 185: 619.
    CrossrefPubMedGoogle Scholar
  • 8 Astrup T, Thorsen S. 1972; The physiology of fibrinolysis. Medical Clinics of North America 56: 153.
    CrossrefPubMedGoogle Scholar
  • 9 Bleyl U, Grözinger K-H, Nagel W, Wanke M. 1967; Histotopochemie aktiver protelytischer Enzyme bei der experimentellen autodigestiven Pankreatitis. Virchows Archiv; Abteilung A: Pathologische Anatomie 342: 26.
    CrossrefPubMedGoogle Scholar
  • 10 Celander D. R, Celander E. 1966; Characterization of fibrinolytic activity of vascular intima. American Journal of Physiology 211: 319.
    PubMedGoogle Scholar
  • 11 Cooper H. A, Bowie E. J. W, Didisheim P, Owen Jr. C. A. 1971; Paradoxic changes in platelets and fibrinogen in chronically induced intravascular coagulation. Mayo Clinic Proceedings 46: 521.
    PubMedGoogle Scholar
  • 12 Cooper H. A, Bowie E. J. W, Owen Jr. C. A. 1973; Chronic induced intravascular coagulation in dogs. American Journal of Physiology 225: 1355.
    PubMedGoogle Scholar
  • 13 Eras P, Harpel P, Winawer S. J. 1970; Histological localization of plasminogen activator and proteolytic activity in the human stomach and duodenum. Gut 11: 851.
    CrossrefPubMedGoogle Scholar
  • 14 Humair L, Potter E. Y, Kwaan H. C. 1969; The role of fibrinogen in renal disease. I. Production of experimental lesions in mice. Journal of Laboratory and Clinical Medicine 74: 60.
    PubMedGoogle Scholar
  • 15 Kester R. C. 1971; The distribution of plasminogen activator in the male genital tract. Journal of Clinical Pathology 24: 726.
    CrossrefPubMedGoogle Scholar
  • 16 Kwaan H. C, Anderson M. C, Gramatica L. 1971; A study of pancreatic enzymes as a factor in the pathogenesis of disseminated intravascular coagulation during acute pancreatitis. Surgery 69: 663.
    PubMedGoogle Scholar
  • 17 Kwaan H. C, Astrup T. (1964a): Fibrinolytic activity of reparative connective tissue. Journal of Pathology and Bacteriology 87: 409.
    PubMedGoogle Scholar
  • 18 Kwaan H. C, Astrup T. (1964b): Localization of fibrinolytic activity in myocardial infarcts in rats. Thrombosis et Diathesis Haemorrhagica 12: 407.
    PubMedGoogle Scholar
  • 19 Kwaan H. C, Astrup T. 1965; Fibrinolytic activity in thrombosed veins. Circulation Research 17: 477.
    CrossrefPubMedGoogle Scholar
  • 20 Kwaan H. C, Astrup T. 1967; Demonstration of cellular, fibrinolytic activity by the histochemical fibrin slide technique. Laboratory Investigation 17: 140.
    PubMedGoogle Scholar
  • 21 Kwaan H. C, Cocco A, Mendelhoff A. I, Astrup T. 1969; Fibrinolytic activity in the normal and inflamed rectal mucosa. Scandinavian Journal of Gastroenterology 04: 441.
    CrossrefPubMedGoogle Scholar
  • 22 Lewis J. H, Ferguson J. H. 1950; Studies on a proteolytic enzyme system of the blood. II. Fibrinolysokinase activators for profibrinolysin. Journal of Clinical Investigation 29: 1059.
    PubMedGoogle Scholar
  • 23 McConnell D, Johnson J. G, Young I, Holemans R. 1966; Localization of plasminogen activator in kidney tissue. Laboratory Investigation 15: 980.
    PubMedGoogle Scholar
  • 24 McKay D. G. 1969; Tissue damage in disseminated intravascular coagulation mechanism of localization of thrombi in the microcirculation. Thrombosis et Diathesis Haemorrhagica Suppl. 36, 67.
    PubMedGoogle Scholar
  • 25 Myhee-Jensen O. 1971; Localization of fibrinolytic activity in the kidney and urinary tract of rats and rabbits. Laboratory Investigation 25: 403.
    PubMedGoogle Scholar
  • 26 Myhre-Jensen O, Astrup T. 1971; Fibrinolytic activity of squamous epithelium of the oral cavity and oesophagus of rat, guinea pig and rabbit. Archives of Oral Biology 16: 1099.
    CrossrefPubMedGoogle Scholar
  • 27 Myhre-Jensen O, Baetz B. A, Astrup T. 1971; Fibrinolytic and proteolytic activity in the rat: histochemical localization in salivary glands, pancreas, and liver. Archives of Pathology 91: 515.
    PubMedGoogle Scholar
  • 28 Myhre-Jensen O, Baetz B. A, Astrup T. 1973; Fibrinolytic activity in rat gastrointestinal mucosa. Archives of Pathology 95: 195.
    PubMedGoogle Scholar
  • 29 Owen Jr. C. A, Bowie E. J. W, Cooper H. A. 1973; Turnover of fibrinogen and platelets in dogs undergoing induced intravascular coagulation. Thrombosis Research 02: 251.
    CrossrefPubMedGoogle Scholar
  • 30 Roberts H. R, Astrup T. 1957; Content of tissue activator of plasminogen in monkey tissues. Thrombosis et Diathesis Haemorrhagica 01: 376.
    PubMedGoogle Scholar
  • 31 Scott G. B. D, Blaszczynski N. 1965; Tissue activator of plasminogen: possible relationship with the generalized Shwartzman reaction. Archives of Pathology 80: 70.
    PubMedGoogle Scholar
  • 32 Silberman S, Potter E. V, Kwaan H. C. 1971; Effects of Arvin in mice: immunofluorescent and histochemical studies. Experimental and Molecular Pathology 14: 67.
    CrossrefPubMedGoogle Scholar
  • 33 Todd A. S. 1958; Fibrinolysis autographs. Nature (London) 181: 495.
    PubMedGoogle Scholar
  • 34 Todd A. S. 1959; The histological localisation of fibrinolysin activator. Journal of Pathology and Bacteriology 78: 281.
    CrossrefPubMedGoogle Scholar
  • 35 Todd A. S. 1964; Localization of fibrinolytic activity in tissues. British Medical Bulletin 20: 210.
    CrossrefPubMedGoogle Scholar
  • 36 Turner R. H, Ryan T. J. 1969; Fibrinolytic activity in human skin. Transactions of the St. John’s Hospital Dermatological Society 55: 212.
    PubMedGoogle Scholar
  • 37 Warren B. A. 1964; Fibrinolytic activity of vascular endothelium. British Medical Bulletin 20: 213.
    CrossrefPubMedGoogle Scholar