Fibrinogen-Fibrin-Related Antigen Pattern in Human Blood

Carl D. Jacobsen; John C. Hoak; Kenneth K. WU; Glenna L. Fry

doi:10.1055/s-0038-1647697

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1974; 32(02/03): 266-276
DOI: 10.1055/s-0038-1647697

Original Article

Schattauer GmbH

Fibrinogen-Fibrin-Related Antigen Pattern in Human Blood

Differences between Plasma and Serum from Patients with Disseminated Intravascular Coagulation

Carl D. Jacobsen

¹Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A

,

John C. Hoak

¹Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A

,

Kenneth K. WU

¹Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A

,

Glenna L. Fry

¹Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A

› Author Affiliations

Abstract

Summary

In serum from patients with DIC at least 3 different FR-antigenic components could be found. It was difficult to demonstrate these components in the corresponding plasma samples. It is possible that a portion of these antigens formed as a result of in vitro clotting despite the presence of proteolytic inhibitors. These results suggest that the interpretation of “increased split products in serum” may be more complex than current concepts indicate.

Full Text

References

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