Fibrinolytic Activity in Rat Anaphylaxis

László Fésüs; Éva Ölveti; Béla Csaba; László Muszbek

doi:10.1055/s-0038-1647703

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1974; 32(02/03): 341-349
DOI: 10.1055/s-0038-1647703

Original Article

Schattauer GmbH

Fibrinolytic Activity in Rat Anaphylaxis

László Fésüs

¹Department of Pathophysiology, University Medical School, 4012 Debrecen, Hungary, and National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014

,

Éva Ölveti

¹Department of Pathophysiology, University Medical School, 4012 Debrecen, Hungary, and National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014

,

Béla Csaba

¹Department of Pathophysiology, University Medical School, 4012 Debrecen, Hungary, and National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014

,

László Muszbek

¹Department of Pathophysiology, University Medical School, 4012 Debrecen, Hungary, and National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014

› Author Affiliations

Abstract

Summary

The activity of fibrinolytic system measured by different methods and the concentration of plasma fibrinogen were determined in rats suffering mild or severe active anaphylactic shock.

In severe anaphylactic shock of Bordetella Pertussis Vaccine pretreated animals, the plasminogen activator content was markedly enhanced and the fibrinolytic activity significantly increased; however, the total inhibitor capacity did not change. The fall in fibrinogen concentration was only moderate. Similar but minor enhancement of fibrinolysis could be observed in mild anaphylaxis.

The results suggest that the activated plasminogen-plasmin system may contribute to the development of severe anaphylactic outcome in the rat. The possible pathogenic mode is discussed.

Full Text

References

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