Amount of Fibrin in Different Organs after Intravenous, Intraportal and Intraaortal Injection of Thrombin in the Rat

Summary

The effect of intravenous, intraaortal and intraportal injection of thrombin on the distribution of intra vascular fibrin in various organs was determined by a quantitative method in the rat. It was found that the major part of the fibrin was trapped in the lungs irrespective of the route of administration of the thrombin.

These results suggest that in thrombin induced intravascular coagulation most of the coagulation occurs on the venous side of the circulation.

This mechanism may be an explanation for the fact that certain organs more often contain intravascular fibrin than others at autopsy.

• References

• 1 Busch C. 1971 Unpublished observation.
• 2 Busch C, Rammer L, Saldeen T. 1973; Quantitation of fibrin deposition and elimination in organs of rats injected with labelled fibrinogen and albumin. Thrombosis et Diathesis Haemorrhagica 29: 94.
• 3 Busch C, Lindquist H, Saldeen T, ThorÉn L. 1971; Determination of intravascular coagulation in vivo in various organs in the dog. VIth Congress of European Society for Experimental Surgery 32.
• 4 Hardaway R. M. Syndromes of Disseminated Intravaseidar Coagulation. Charles C. Thomas, Publisher; Springfield, Illinois: 1966
• 5 Lewis J, HSzeto I. L. F. 1965; Clearance of infused fibrin. Federation Proceedings 24 840.
• 6 Lindquist O, Rammer L, Saldeen T. 1972; Pulmonary insufficiency, microembolism and fibrinolysis inhibition in a post-traumatic autopsy material. Acta chirurgica Scandinavica 138: 545.
• 7 McKay D. G. 1965. Disseminated Intravaseidar Coagulation. An Intermediary Mechanism of Disease. Hoeber Medical Division. Harper and Row, Publishers; New York.:
• 8 McKay D. G, Linder M. M, Kruse V. K. 1971; Mechanisms of Thrombosis of the Microcirculation. American Journal of Pathology 63: 231.
• 9 Nilsson I, MOlow B. 1962; Determination of fibrinogen and fibrinogenolytie activity. Thrombosis et Diathesis Haemorrhagica 08: 297.
• 10 Olsson P, Delin A. 1965; Femoral arterial flow changes following intraarterial injection of thrombin and thromboplastin. Transactions of the American Society for Artificial Internal Organs. 11 318.
• 11 Rammer L, Busch C, Diffang C, Saldeen T. 1972; The amount of fibrin in various organs after intravenous infusion of thrombin in rats with special reference to the heart. Forensic Science 01: 115.
• 12 Regoeczi E, Brain M. C. 1969; Organ Distribution of Fibrin in Disseminated Intravascular Coagulation. British Journal of Haematology 17: 73.
• 13 Saldeen T. 1964. Om fibr inför ekomsten i lungorna. Nordisk Rettsmed. Forenings Forhandl. Oslo: Universitetsförlaget; 211.
• 14 Saldeen T. 1966; Experimental investigation on fat embolism and intravascular coagulation. Acta pathologica et microbiologica Scandinavica 66: 271.
• 15 Saldeen T. 1967; The occurrence of Fibrin in the Lungs in an Autopsy Material. Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin 343: 20.
• 16 Saldeen T. 1969; Quantitative Determination of Intravascular coagulation in the Lungs of Experimental Animals. Scandinavian Journal of Haematology 06: 206.
• 17 Saldeen T. 1970; Fat Embolism and signs of Intravascular Coagulation in a Posttraumatic Autopsy Material. Journal of Trauma 10 273.
• 18 Saldeen T, Bagge L, Busch C, Rammer L. 1972; Delayed fibrin elimination from the lungs and pulmonary damage after intravenous injection of thrombin in rats with endogenous inhibition of the fibrinolytic system. Forensic Science 01: 115.
• 19 Sapirstein L. A. 1958; Regional Blood Flow by fractional Distribution of Indicators. American Journal of Physiology 193 161.
• 20 Swedenborg J. 1971; Thrombin induced vasocinstriction in the pulmonary circulation. Scandinavian Journal of Clinical and Laboratory Investigation 27: 321.
• 21 Wiedeman M. P. 1963; Dimensions of Blood Vessels from Distributing Artery to Collecting Vein. Circulation Research 12: 375.