Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1973; 29(02): 393-407
DOI: 10.1055/s-0038-1647780

Original Article

Schattauer GmbH

Studies on Thrombolysis with Streptokinase

IV. Immunofluorescent Investigations on the Fibrin Pattern and the Content of Plasminogen and of Plasma-Plasmin-Inhibitors in Clots and Thrombi of Various Age

R Gottlob

¹Department of Experimental Surgery (Head: Prof. Dr. R. Gottlob) of the Ist Surgical Clinic (Head: Prof. Dr. P. Fuchsig) Vienna University, Alserstraße 4, Vienna IX Austria, and the Ist Surgical Department of the Vienna Municipal Hospital, Lainz (Head: Doz. Dr. H. Denck)

,

B El Nashef

¹Department of Experimental Surgery (Head: Prof. Dr. R. Gottlob) of the Ist Surgical Clinic (Head: Prof. Dr. P. Fuchsig) Vienna University, Alserstraße 4, Vienna IX Austria, and the Ist Surgical Department of the Vienna Municipal Hospital, Lainz (Head: Doz. Dr. H. Denck)

,

P Donas

¹Department of Experimental Surgery (Head: Prof. Dr. R. Gottlob) of the Ist Surgical Clinic (Head: Prof. Dr. P. Fuchsig) Vienna University, Alserstraße 4, Vienna IX Austria, and the Ist Surgical Department of the Vienna Municipal Hospital, Lainz (Head: Doz. Dr. H. Denck)

,

F Piza

¹Department of Experimental Surgery (Head: Prof. Dr. R. Gottlob) of the Ist Surgical Clinic (Head: Prof. Dr. P. Fuchsig) Vienna University, Alserstraße 4, Vienna IX Austria, and the Ist Surgical Department of the Vienna Municipal Hospital, Lainz (Head: Doz. Dr. H. Denck)

,

R Kolb

¹Department of Experimental Surgery (Head: Prof. Dr. R. Gottlob) of the Ist Surgical Clinic (Head: Prof. Dr. P. Fuchsig) Vienna University, Alserstraße 4, Vienna IX Austria, and the Ist Surgical Department of the Vienna Municipal Hospital, Lainz (Head: Doz. Dr. H. Denck)

› Institutsangaben

Summary

The patterns of fibrin and the contents of plasminogen, of α₁ antitrypsin and of a₂-macroglobulin were studied in whole blood clots before and after retraction and in arterial and venous thrombi of various age by an indirect immunofluorescent method.

By reaction with antifibrinogen a network of fibrin fibers was displayed in the first week. The fibers were condensed to form trabecula in the first months. After several months the reaction with antifibrinogen was reduced or abolished even in non organized thrombi.

In clots and thrombi the plasminogen content is lost during retraction, However, a considerable increase is observed in thrombi up to several months old.

The plasma plasmin inhibitors are only partially expressed during retraction. Later a considerable increase may occur.

The relevance of these findings for thrombolysis is discussed.

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