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Thromb Haemost 1973; 29(02): 445-449
DOI: 10.1055/s-0038-1647784
Original Article
Schattauer GmbH

Enhancement by ADP of Thrombin-induced Aggregation in ADP-refractory Platelets

Nicole Simard-Duquesne
1   Ayerst Research Laboratories, Montreal, Quebec, Canada
› Author Affiliations
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Publication History

Received for publication 09 October 1972

Publication Date:
24 July 2018 (online)

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Summary

In ADP-refractory rat platelets, thrombin-induced aggregation is enhanced in the presence of ADP and inhibited in the absence of ADP. Two mechanisms are proposed for thrombin-induced platelet aggregation: one through ADP release which may become refractory, and a second mechanism in which thrombin acts synergistieally with ADP.

 

  • References

  • 1 Adam H. 1963. Adenosine-5’-diphosphate and Adenosine-5’-monophosphate. In: Bergmeyer H. U. (ed.), Methods of Enzymatic Analysis. Academic Press; New York: 573.
    Search in Google Scholar
  • 2 Born G. V. R, Cross M. J. 1963; The aggregation of blood platelets. Journal of Physiology 168: 178.
    CrossrefPubMedSearch in Google Scholar
  • 3 Btjsfield D, Tomich E. G. 1967; Reduction of platelet adhesiveness by adenosine diphosphate and triphosphate. Nature 214: 1360.
    CrossrefPubMedSearch in Google Scholar
  • 4 Haslam R. J. 1964; Role of adenosine diphosphate in the aggregation of human blood-platelets by thrombin and by fatty acids. Nature 202: 765.
    CrossrefPubMedSearch in Google Scholar
  • 5 Niewiarowski S, Thomas D. P. 1966; Platelet aggregation by ADP and thrombin. Nature 212: 1544.
    CrossrefPubMedSearch in Google Scholar
  • 6 O’Brien J. R. 1966; Changes in platelet membranes possibly associated with platelet stickiness. Nature 212: 1057.
    CrossrefPubMedSearch in Google Scholar
  • 7 O’Brien J. R, Etherington M, Jamieson S. 1971; Refractory state of platelet aggregation with major operations. Lancet II: 741.
    PubMedSearch in Google Scholar
  • 8 Packham M. A, Chang P-L, Guccione M. A. 1972; Early changes during platelet aggregation induced by thrombin or collagen. Federation Proceedings 31: 242.
    PubMedSearch in Google Scholar
  • 9 Regoli D, Clark V. 1963; Prevention by adenosine of the effect of adenosine diphosphate on the concentration of circulating platelets. Nature 200: 546.
    CrossrefPubMedSearch in Google Scholar
  • 10 Renaud S, Kuba K, Goulet C, Lemire Y, Allard C. 1970; Relationship between fatty-acid composition of platelets and platelet aggregation in rat and man. Circulation Research 26: 553.
    CrossrefPubMedSearch in Google Scholar
  • 11 Rodman N. F, Mason R. G. 1967; Platelet-platelet interaction: relationship to hemostasis and thrombosis. Federation Proceedings 25: 95.
    PubMedSearch in Google Scholar
  • 12 Sinakos Z, Caen J. P. 1967; Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog) a comparative study. Thrombosis et Diathesis Haemorrhagica 17: 99.
    PubMedSearch in Google Scholar
  • 13 Zbinden G, Grimm L, Muheim M. 1971; Aggregation of platelets remaining in circulation after acute thrombosis. Thrombosis et Diathesis Haemorrhagica 25: 517.
    PubMedSearch in Google Scholar