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Thromb Haemost 1975; 33(02): 217-220
DOI: 10.1055/s-0038-1647874
Original Article
Schattauer GmbH

The Effect of Brinase on Fibrinogen in Vivo

D Nyman
1   Coagulation and Fibrinolysis Laboratory of the Dept. for Internal Medicine, University of Basle, Switzerland
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Further Information

Publication History

Received 17 December 1974

Accepted 20 February 1975

Publication Date:
02 July 2018 (online)

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Summary

Brinase infusions in man cause, without excessive lowering of the inhibitor capacity, a slowing of the fibrin polymerization. This is combined with a degradation of the A α chain into two major fragments. Both fragments carry crosslinking sites. Brinase infusion also causes positive ethanol gelation. Evidence for the formation of γ dimers was found.

 

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