The Effect of Beta Adrenergic Blockade upon Exercise-Induced Changes in Blood Coagulation and Fibrinolysis

B.J Britton; W.G Wood; Muriel Smith; Christine Hawkey; M.H Irving

doi:10.1055/s-0038-1647934

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 35(02): 396-402
DOI: 10.1055/s-0038-1647934

Original Article

Schattauer GmbH

The Effect of Beta Adrenergic Blockade upon Exercise-Induced Changes in Blood Coagulation and Fibrinolysis

B.J Britton

¹Surgical Unit, St. Bartholomews Hospital, London EC 1; Nuffield Institute of Comparative Medicine, Regents Park, London NW I; Department of Surgery, Hope Hospital, Salford, Lanes.

,

W.G Wood

¹Surgical Unit, St. Bartholomews Hospital, London EC 1; Nuffield Institute of Comparative Medicine, Regents Park, London NW I; Department of Surgery, Hope Hospital, Salford, Lanes.

,

Muriel Smith

¹Surgical Unit, St. Bartholomews Hospital, London EC 1; Nuffield Institute of Comparative Medicine, Regents Park, London NW I; Department of Surgery, Hope Hospital, Salford, Lanes.

,

Christine Hawkey

¹Surgical Unit, St. Bartholomews Hospital, London EC 1; Nuffield Institute of Comparative Medicine, Regents Park, London NW I; Department of Surgery, Hope Hospital, Salford, Lanes.

,

M.H Irving

¹Surgical Unit, St. Bartholomews Hospital, London EC 1; Nuffield Institute of Comparative Medicine, Regents Park, London NW I; Department of Surgery, Hope Hospital, Salford, Lanes.

› Author Affiliations

Abstract

Summary

Exercise stress is known to stimulate blood coagulation and fibrinolysis possibly as a result of sympatho-adrenal stimulation of the beta adrenergic receptor. In order to test this hypothesis five men exercised on four separate occasions with and without prior beta adrenergic blockade with oxprenolol, propranolol and pindolol. The increase in plasma adrenaline and noradrenaline concentration was much greater during exercise under beta blockade but activation of fibrinolysis was enhanced as well. Factor VIII levels did not change significantly during any of the experiments. These results suggest that the activation of fibrinolysis by exercise is not mediated by the beta adrenergic receptor. The influence of beta adrenergic blockade on the change in factor VTII with exercise was inconclusive.

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References

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