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Thromb Haemost 1976; 35(02): 415-422
DOI: 10.1055/s-0038-1647936
Original Article
Schattauer GmbH

Blood Coagulation and Fibrinolysis in Thyroid Disease

Nadir R. Farid
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
,
Brian L. Griffiths
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
,
John R. Collins
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
,
William H. Marshall
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
,
David Wallace Ingram
1   General Hospital and The Faculty of Medicine Memorial University of Newfoundland St. John’s, Newfoundland, Canada A1C 5S7
› Author Affiliations
Further Information

Publication History

Received 11 June 1975

Accepted 12 August 1975

Publication Date:
02 July 2018 (online)

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Summary

Fibrinolytic activity and factor VIII concentration were studied in 30 patients with moderate to minimal hypothyroidism and in 7 patients with hyperthyroidism. In the hypothyroid group, the results were related to serum thyroxine levels, HL-A phenotypes and thyroid autoantibody titres. As serum thyroxine decreased so did factor VIII concentration, however, euglobulin lysis time was correspondingly prolonged. Factor VIII appears to be the most sensitive among coagulation factors to the deterioration of thyroid function tests. There was a significant correlation between the reciprocal of thyroid antibody titres and fibrinolysis; however, there was no relationship between factor VIII concentration or fibrinolysis and a specific HL-A phenotype although the incidence of HL-A8 was increased in the group as a whole.

Euglobulin lysis time was prolonged in 6 out of 7 patients with Graves’ hyperthyroidism. Factor VIII was elevated in only 3 of these patients.

 

  • References

  • 1 Allington J. J. 1971; Detection of fibrin(ogen) degradation products by a latex clumping method. Scandinavian Journal of Haematology. Supplement 13: 115.
    PubMedSearch in Google Scholar
  • 2 Bastenie P. S, Van Haelst L, Neve P. 1972. Thyroiditis and Thyroid Function. Pergamon Press; New York: 275.
    CrossrefSearch in Google Scholar
  • 3 Biggs R. 1972. Human blood coagulation, haemostasis and thrombosis. Blackwell Scientific Publication; London: 634
    Search in Google Scholar
  • 4 Borhani O. N. 1972; Endocrine Factors and Venous Thrombosis. The Milk Bank Memorial Fund Quarterly p. 50, 1 (02) 31.
    PubMedSearch in Google Scholar
  • 5 Buckell M. 1958; The Effect of citrate on euglobulin methods of estimating fibrinolytic activity. Journal of Clinical Pathology 11: 403.
    CrossrefPubMedSearch in Google Scholar
  • 6 Dinternfass L, Stewart J. W, Milton G. W, Forbes C. D. 1973; The influence of ABO blood groups and fibrinogen on thrombus formation and aggregation of red cells in cardiovascular and malignant diseases. New aspects of biorheological characterization of disease. Biorheology 10: 585.
    PubMedSearch in Google Scholar
  • 7 Doniach D. 1967; Thyroid auto-immune disease. Journal of Clinical Pathology-Supplement 20: 385.
    PubMedSearch in Google Scholar
  • 8 Edson J. R, Fecher D. R, Doe R. P. 1975; Low platelet adhesiveness and other hemostatic abnormalities in hypothyroidism. Annals of Internal Medicine 82: 342.
    CrossrefPubMedSearch in Google Scholar
  • 9 Egeberg O. 1963; Influence of thyroid function on blood clotting system. Scandinavian Journal of Clinical and Laboratory Investigation 15: 1.
    CrossrefPubMedSearch in Google Scholar
  • 10 Evered D. C, Hall R. 1973; Grades of hypothyroidism. British Medical Journal 3: 695.
    PubMedSearch in Google Scholar
  • 11 Farid N. R, Barnard J, Kutas C, Noel E. P, Marshall W. H. 1975; HL-A antigens in Graves’ Disease and Hashimoto’s thyroiditis. International Archives of Allergy and Applied Immunology 49: 837.
    CrossrefPubMedSearch in Google Scholar
  • 12 Grumet C. F, Payne R. O, Konishi J, Kriss J. P. 1974; HL-A antigens as markers for disease susceptibility and autoimmunity in Graves’ disease. Journal of Clinical Endocrinology and Metabolism 39: 1115.
    CrossrefPubMedSearch in Google Scholar
  • 13 Hardisty R. M, MacPherson J. C. 1962; A one-stage Factor VIII (antihaemphilic globulin) assay and its use on venous and capillary plasma. Thrombosis et Diathesis Haemorrhagica 7: 215.
    PubMedSearch in Google Scholar
  • 14 Korsan-Bengsren K, Thor-Bjorn C. 1974; Influence of two different Beta-Adrenergic Blocking agents on the increase in fibrinolytic activity and factor VIII activity during submaximum and maximum exercise. Scandinavian Journal of Haematology 13: 311.
    PubMedSearch in Google Scholar
  • 15 Masi A. T. 1972; Endocrine factors and risk of venous thrombosis. Milbank Memorial Fund Quarterly 50 (01) Supl. 2: 46.
    CrossrefPubMedSearch in Google Scholar
  • 16 Matthews J. D, Whtttingham S, Mackay I. R. 1974; Autoimmune mechanisms in human vascular disease. Lancet 77: 1423.
    PubMedSearch in Google Scholar
  • 17 Mittal K. K, Mickey M. R, Singal P. F, Teresaki P. I. 1968; Serotyping for homo transplantation. Transplantation 6: 913.
    CrossrefPubMedSearch in Google Scholar
  • 18 Murphy B. E. P, Pattee C. J, Gold A. 1966; Clinical evaluation of a new method for determination of serum thyroxine. Journal of Clinical Endocrinology and Metabolism 26: 247.
    CrossrefPubMedSearch in Google Scholar
  • 19 Napiorkowska W, Palester-Cheebowezyk M, Keydana-Jedrzejewska B, Strzysewska E. 1972; The pattern of blood clotting and fibrinolytic systems in hyperthyreosis. Endokrynologia Polska 23: 423.
    PubMedSearch in Google Scholar
  • 20 Odell W. D, Utiger R. D, Wilber J. 1967; Studies of thyrotrophin physiology by means of radioimmunoassays. Recent Progress in Hormonal Research 23: 47.
    PubMedSearch in Google Scholar
  • 21 Ormston B. J, Garry R, Cyrer R. J, Besser G. M, Hall R. 1971; Thyrotrophin Releasing Hormone as a thyroid function test. Lancet II: 10.
    PubMedSearch in Google Scholar
  • 22 Owren P. A. 1959; Thrombotest. A. new method for controlling anticoagulant therapy. Lancet 17: 754.
    PubMedSearch in Google Scholar
  • 23 Panchenko V. M, Antonidze A. V. 1973; Blood Coagulation in patients with toxic goiter. Problem Endokrinologii (Moskva) 19: 22.
    PubMedSearch in Google Scholar
  • 24 Simone J. V, Abtlgaard C. F, Scholman I. 1965; Blood coagulation in thyroid dysfunction. The New England Journal of Medicine 273: 1057.
    CrossrefPubMedSearch in Google Scholar
  • 25 Sisson J. V. 1965; Principles of and pitfalls in thyroid function tests. Journal of Nuclear Medicine 6: 853.
    PubMedSearch in Google Scholar