Comparison of the Actions of Thrombin and the Thrombin-Like Venom Enzymes Ancrod and Batroxobin

D. L Aronson

doi:10.1055/s-0038-1648004

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 36(01): 009-013
DOI: 10.1055/s-0038-1648004

Original Article

Schattauer GmbH

Comparison of the Actions of Thrombin and the Thrombin-Like Venom Enzymes Ancrod and Batroxobin

D. L Aronson

¹Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland 20014

› Author Affiliations

Abstract

Summary

Thrombin acts on several coagulant proteins to produce products with physiologic, pharmacologic and pathologic potential. The most sensitive thrombin substrate seems to be factor VIII. Some thrombin dependent reactions studied in vitro and proposed as control reactions seem too insensitive to the action of thrombin to be of in vivo significance.

The only enzymic reaction the thrombin-like venom enzymes, Ancrod and Batroxobin, have in common with thrombin is the removal of fibrinopeptide A.

Full Text

References

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