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Thromb Haemost 1976; 36(01): 086-089
DOI: 10.1055/s-0038-1648012
DOI: 10.1055/s-0038-1648012
Original Article
Failure of Immunosuppression in a Severe Haemophilia B Patient with Specific Antibody
Further Information
Publication History
Received
30 March 1976
Accepted
12 April 1976
Publication Date:
03 July 2018 (online)
Summary
Prevention of a secondary response to factor IX by cyclophosphamide was attempted in an 11 year old patient with severe Christmas disease. An antibody to factor IX had been present for 4 years before immunosuppressive therapy was tried. Despite profound lymphopenia, synthesis of factor IX antibody was not depressed. The difficulties of modifying the anamnestic response to factor IX by chemical immunosuppression may be as real as has been reported for factor VIII in classical haemophilia.
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References
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