Potentiating Effect of Adenosine on Other Inhibitors of Platelet Aggregation

M. Murakami; K. Odake; M. Takase; K. Yoshino

doi:10.1055/s-0038-1649364

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 27(02): 252-262
DOI: 10.1055/s-0038-1649364

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Potentiating Effect of Adenosine on Other Inhibitors of Platelet Aggregation

M. Murakami M. D.

¹The Second Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan

,

K. Odake M. D.

¹The Second Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan

,

M. Takase M. D.

¹The Second Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan

,

K. Yoshino M. D.

¹The Second Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan

› Author Affiliations

Abstract

Summary

Adenosine was rapidly incorporated into human platelets, and the inhibitory effect of adenosine on platelet aggregation was correlated with the incorporation process. Adenosine potentiated the inhibitory action of other inhibitors, such as dipyridamole, prostaglandin E₁ and Y-3642. The inhibition of aggregation was associated with the preservation of platelet adenine nucleotides and the prevention of ADP release. On the other hand, the radioactive adenine nucleotide pattern of platelets was not substantially affected by inhibitors. The relation of inhibition of aggregation with ADP release was discussed.

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References

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