Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1968; 19(01/02): 001-011DOI: 10.1055/s-0038-1650203 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH Localization of Inhibition of Platelet Aggregation by Incubation of Platelet Rich EDTA-Plasma at 37°C R Gross 1 Medical Clinic of the University of Cologne (Head: Prof. Dr. R. Gross) , G Niemeyer 1 Medical Clinic of the University of Cologne (Head: Prof. Dr. R. Gross) , H Reuter 1 Medical Clinic of the University of Cologne (Head: Prof. Dr. R. Gross) › Author Affiliations Recommend Article Abstract Buy Article Summary By photometric and microscopic technics investigations have been carried out to determine the nature of the inhibition of platelet aggregation caused by incubating platelet rich EDTA-plasma at 37° C. The results clearly indicate that the inhibition must arise from alterations in the platelets themselves. The appearance of an inhibitory substance in plasma and the release of such a substance from the platelets into the plasma have been excluded. Addition of ADP to the inhibited platelets did not influence the inhibition of platelet aggregation. Full Text References References 1 Born G.V.R. Quantitative investigations into the aggregation of blood platelets. J. Physiol. 1962; 162: 67 2 Gross R, Niemeyer G, Reuter H. Untersuchungen über die Aggregation menschlicher Blutplättchen 1. Mitteilung : Standardisierte Methoden zur quantitativen Bestimmung der Aggregation. Klin. Wschr. 1967; 45: 931 3 Des Prez R.M, Bryant R.E, Katz J.A, Brittingham Th.E. Platelet aggregation by Magnesium ions. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 27: 516 4 Niemeyer G, Reuter H, Gross R. Untersuchungen über die Aggregation menschlicher Blutplättchen 2. Mitteilung: Über den Einfluß der Temperatur auf die Plättchenaggregation. Klin. Wschr. 1967; 45: 1142 5 Reuter H, Niemeyer G, Gross R. Untersuchungen über die Aggregation menschlicher Blutplättchen 3. Mitteilung: Über den Einfluß der Inkubation von EDTA-Plasma bei 37̊ C auf die Plättchenaggregation. Klin. Wschr. 1967; 45: 1147 6 Born G.V.R, Cross M.J. Effects of inorganic ions and of plasma proteins on the aggregation of blood platelets by adenosine diphosphate. J. Physiol. 1964; 170: 397 7 O’Brien J.R. Platelet aggregation. I. Some effects of the adenosine phosphates, thrombin, and cocaine upon platelets. — II. Some findings with a new method of study. J. clin. Pathol. 1962; 15: 446-456 8 O’Brien J.R. A comparison of platelet aggregation produced by seven compounds and a comparison of their inhibitors. J. clin. Path. 1964; 17: 275 9 Constantine J.W. Temperature and the aggregation of rabbit platelets by adenosine diphosphate.. Nature (Lond.) 1965; 205: 1075
