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DOI: 10.1055/s-0038-1651237
Release of Platelet Factor 4 in Vivo during Intravascular Coagulation and in Thrombotic States
Publication History
Publication Date:
27 June 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/196801/lookinside/thumbnails/10-1055-s-0038-1651237-1.jpg)
Summary
Platelet factor 4 released from platelets into the circulating blood was determined using both the heparin thrombin time and paracoagulation methods. It has been found that thrombin injected intravenously into rabbits releases large amounts of this factor. Infusion of plasmin does not release this factor and this finding may be of importance for the differential diagnosis between disseminated intravascular clotting and primary fibrinolysis. PF4 is not released during the hyper coagulable condition induced by HgCl2 intoxication. Only small amounts of this factor are released after contact factor infusion.
A significant elevation of extraplatelet PF4 was found in 23 patients with fresh coronary thrombosis and in 9 patients with thrombophlebitis and thromboembolic complications.
The significance of the above findings for the pathogenesis, treatment and laboratory diagnosis of thrombotic diseases with particular reference to heparin tolerance test is discussed.
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References
- 1 Farbiszewski R, Lipinski B, Niewiarowski S, Poptawski A. Hypercoagulability and thrombocytopenia after platelet factor 4 infusion into rabbits. Experientia (Basel).(In press.).
- 2 Gurewich V, Thomas D.P. Pathogenesis of venous thrombosis in relation to its prevention by dextran and heparin.. J. Lab. clin. Med 1965; 66: 604
- 3 Lipinski B, Worowski K. Detection of soluble fibrin monomer complexes in human plasma by means of protamine sulphate test., Thrombos. Diathes. haemorrh. (Stuttg.).(Submitted for publication.).
- 4 Lipinski B, Worowski K, Jeliaszewicz J, Niewiarowski S, Bejniak L. The role of soluble fibrin monomer complexes and platelet factor 4 in the generalized Schwartzman reaction., Thrombos. Diath. haemorrh. (Stuttg.).(Submitted for publication.).
- 5 Niewiarowski S, Lipiński B, Farbiszewski R, Poplawski A. The release of platelet factor 4 during platelet aggregation and the possible significance of this reaction in hemostasis.. Experientia (Basel) 1968; 24: 343
- 6 Niewiarowski S, Poplawski A, Lipiński B, Farbiszewski R. The release of platelet clotting factors during aggregation and viscous metamorphosis. Conference “Platelets in Hemostasis” Miemo, Italy, Sept. 1967. Exp. Biol. Med. 3 (In press.) 1968
- 7 Niewiarowski S, Stachurska J, Węgrzynowicz Z. Arginine esterase activity of the contact (Hageman) factor.. Thrombos. Diathes. haemorrh. (Stuttg.) 1962; 7: 514
- 8 Niewiarowski S, Rogowicka-Gorzelak I, Worowski K, Myśliwiec M. The in vivo effect of the colagen or kaolin-activated contact factor on blood clotting and fibrinolysis in rabbit.. Bull. Acad. Polon. Sci. Ser. Sci. Biol 1967; 15: 599
- 9 Niewiarowski S, Żwyicka H, Latallo Z. Coagulation disorders in thrombocythaemia. A study of seven cases.. Thrombos. Diathes. haemorrh. (Stuttg.) 1962; 7: 114
- 10 O’Brien J.R. The effect of heparin on the early stages of blood coagulation.. J. clin. Path 1960; 73: 93
- 11 Poller J. The theory and practice of anticoagulant treatment Bristol John Wright and Sons Ltd 1962
- 12 Quick A.J. Hemorrhagic Diseases. Lea and Febiger, Philadelphia 1954
- 13 Rees H.M, Ecker E.E. An improved method for counting platelets.. JAMA 1923; 80: 621
- 14 Soulier J.P, Larrieu M.J. Les anticoagulants en therapeutique Paris Doin et Cie 1955
- 15 Waugh T.R, Ruddick D.W. A test for increased coagulability of blood.. Canad. med. Ass. J 1944; 50: 547
- 16 Worowski K, Niewiarowski S, Prokopowicz J. Fibrinolysis and fibrinogen breakdown products (antithrombin VII in renal venous blood (RVB) in dog.. Thrombos. Diathes. haemorrh. (Stuttg.) 1964; 12: 87
- 17 Worowski K. The hypercoagulability in mercury chloride intoxicated dogs.. Thrombos. Diathes. haemorrh. (Stuttg.) 1968; 19: 236