Plasma Fibrinolytic Activity Following Oral Anabolic Steroid Therapy

I. D Walker; J. F Davidson; P Young; J. A Conkie

doi:10.1055/s-0038-1651371

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1975; 34(01): 236-245
DOI: 10.1055/s-0038-1651371

Original Article

Schattauer GmbH

Plasma Fibrinolytic Activity Following Oral Anabolic Steroid Therapy

I. D Walker

¹Department of Haematology, Royal Infirmary, Glasgow

,

J. F Davidson

¹Department of Haematology, Royal Infirmary, Glasgow

,

P Young

¹Department of Haematology, Royal Infirmary, Glasgow

,

J. A Conkie

¹Department of Haematology, Royal Infirmary, Glasgow

› Author Affiliations

Abstract

Summary

Six anabolic steroids were assessed for their ability to enhance plasma fibrinolytic activity in males with ischaemic heart disease. Five 17α-alkylated steroids (Ethyloestrenol, Norethandrolone, Methandienone, Methylandrostenediol and Oxymetholone) were examined and all produced a significant increase in plasma plasminogen activator as measured by the euglobulin lysis time. The only non-17α-alkylated steroid studied (Methenolone acetate) failed to enhance fibrinolysis. The 17α-alkylated steroids studied all deserve more detailed evaluation of their long term effects on plasma fibrinolytic activity.

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References

References
1 Back N, Wilkens H, Barlow B, and Czarnecki J. 1968; Fibrinolytic studies with biguanide derivatives. Annals of the New York Academy of Sciences 148: 691.
2 Chakrabarti R, Hocking E. D, Fearnley G. R, Mann R. D, Attwell T. N, and Jackson D. 1968; Fibrinolytic acitivity and Coronary artery disease. Lancet I: 987.
3 Chakrabarti R, Evans J. F, and Fearnley G. R. 1970; Effect on Platelet stickiness and fibrinolysis of phenformin combined with ethyloestrenol of stanozolol. Lancet I: 591.
4 Davidson J. F, Lochhead M, McDonald G. A, and McNicol G. P. 1972; Fibrinolytic enhancement by Stanozolol. A double blind trial. British Journal of Haematology 22: 543.
5 Dixon W. J, and Massey F. J. 1957. Introduction to Statistical Analysis. 2nd Edition.. 124. McGraw Hill Book Company Incorporated.;
6 Fearnley G. R, and Chakrabarti R. 1964; Pharmacological enhancement of fibrinolytic activity of blood. Journal of Clinical Pathology 17: 328.
7 Fearnley G. R, Chakrabarti R, and Evans J. F. 1969; a Fibrinolytic and defibrin-ating effect of phenformin plus ethyloestrenol in vivo. Lancet 1: 910.
8 Fearnley G. R. 1969. b Fibrinolysis. In: Recent Advances in Blood Coagulation. Poller L. (ed.) Churchill; London: 229.
9 Isacson S, and Nilsson I. M. 1970; Effect of treatment with combined Phenformin and Ethyloestrenol on the coagulation and fibrinolytic systems. Scandinavian Journal of Haematology 7: 404.
10 Isacson S. 1971; Low fibrinolytic activity of blood and vein walls in venous thrombosis. Scandinavian Journal of Haematology, Supplement 16: 21.
11 McNicol G. P, Gale S. B, and Douglas A. S. 1963; In vitro and In vivo studies of a preparation of Urokinase. British Medical Journal I: 909.
12 Merskey C, Kleiner G. J, and Johnson A. J. 1966; Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood 28: 1.
13 Nilsson I. M, and Olow B. 1962; Fibrinolysis induced by streptokinase in man. Acta Chirurgica Scandinavica 123: 247.
14 Nilsson I. M, Hedner U, and Isacson S. 1947 Phenformin and Ethyloestrenol in recurrent venous thromboses. Proceedings of the 2nd International Congress on Synthetic Fibrinolytic Agents, Paris (in press).
15 Sherry S, and Alkjaersig N. 1957; A study of the fibrinolytic enzyme of human plasma. Thrombosis et Diathesis Haemorrhagica 1: 264.
16 Wolf P. 1967; Coagulation fibrinolysis (Letter). Lancet I: 1226.