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Thromb Haemost 1975; 34(02): 475-482
DOI: 10.1055/s-0038-1651406
Original Article
Schattauer GmbH

Serial Changes in the Coagulation System Following Clotting Factor Concentrate Infusion

F. E Preston
1   University Department of Haematology, The Royal Infirmary, Sheffield S63 DA, England
,
D. A Winfield
1   University Department of Haematology, The Royal Infirmary, Sheffield S63 DA, England
,
R. G Malia
1   University Department of Haematology, The Royal Infirmary, Sheffield S63 DA, England
,
E. K Blackburn
1   University Department of Haematology, The Royal Infirmary, Sheffield S63 DA, England
› Author Affiliations
Further Information

Publication History

Received 17 January 1975

accepted 28 April 1975

Publication Date:
02 July 2018 (online)

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Summary

Various parameters of the coagulation system have been monitored in patients with Christmas disease following the infusion of clotting factor concentrates. Significant reduction of clotting factor VIII and serum antithrombin III were observed in each of the five studies, whilst the plasma fibrinogen level fell in four subjects. The induced abnormalities were shortlived and there were no clinical sequelae. Further studies are required to assess the effects of similar concentrates in patients with liver disease.

 

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