Serial Changes in the Coagulation System Following Clotting Factor Concentrate Infusion

F. E Preston; D. A Winfield; R. G Malia; E. K Blackburn

doi:10.1055/s-0038-1651406

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1975; 34(02): 475-482
DOI: 10.1055/s-0038-1651406

Original Article

Schattauer GmbH

Serial Changes in the Coagulation System Following Clotting Factor Concentrate Infusion

F. E Preston

¹University Department of Haematology, The Royal Infirmary, Sheffield S63 DA, England

,

D. A Winfield

¹University Department of Haematology, The Royal Infirmary, Sheffield S63 DA, England

,

R. G Malia

¹University Department of Haematology, The Royal Infirmary, Sheffield S63 DA, England

,

E. K Blackburn

¹University Department of Haematology, The Royal Infirmary, Sheffield S63 DA, England

› Author Affiliations

Abstract

Summary

Various parameters of the coagulation system have been monitored in patients with Christmas disease following the infusion of clotting factor concentrates. Significant reduction of clotting factor VIII and serum antithrombin III were observed in each of the five studies, whilst the plasma fibrinogen level fell in four subjects. The induced abnormalities were shortlived and there were no clinical sequelae. Further studies are required to assess the effects of similar concentrates in patients with liver disease.

Full Text

References

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