The Filtragometer: A New Device for Measuring Platelet Aggregation in Venous Blood of Man

G Hornstra; F ten Hoor

doi:10.1055/s-0038-1651412

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1975; 34(02): 531-544
DOI: 10.1055/s-0038-1651412

Original Article

Schattauer GmbH

The Filtragometer: A New Device for Measuring Platelet Aggregation in Venous Blood of Man

Authors

G Hornstra

¹From Unilever Research, Vlaardingen, The Netherlands
F ten Hoor

¹From Unilever Research, Vlaardingen, The Netherlands

Abstract

Summary

A new device for the direct assessment of spontaneous platelet aggregation in human venous blood is described: the Filtragometer. The principle of the method is based on measurement of the pressure difference across a filter with pores of 20 μπι diameter through which blood from a forearm vein is drawn. Platelet aggregates, obstructing the filter, cause a change in the pressure difference which is proportional to the degree of platelet aggregation. The measurement takes only a short time and a small amount (5-10 ml) of blood.

Platelet aggregation as measured with the Filtragometer depends on the type of anticoagulant used. The Filtragometer response decreases on inhibition of platelet stickiness in vitro by prostaglandin E₁ and in vivo by aspirin ingestion. Moreover it appeared to be higher in a group with a high thrombosis tendency than in a group less susceptible to fatal arterial thrombosis.

The Filtragometer seems especially useful in monitoring the results of diet and/or drug therapy.

Full Text

References

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