The Effect of Chronic Administration of Lathyrogen (Beta-Aminopropionitrile) on Blood Clotting and Fibrinolytic System in Rabbits

E Bańkowski; K Worowski

doi:10.1055/s-0038-1651417

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1969; 22(02): 372-376
DOI: 10.1055/s-0038-1651417

Originalarbeiten-Original Articles-Travaux Originaux

Schattauer GmbH

The Effect of Chronic Administration of Lathyrogen (Beta-Aminopropionitrile) on Blood Clotting and Fibrinolytic System in Rabbits

E Bańkowski

¹Department of Physiological Chemistry, Medical School, Białystok, Poland

,

K Worowski

¹Department of Physiological Chemistry, Medical School, Białystok, Poland

› Institutsangaben

Abstract

Summary

The effect of chronic intoxication of rabbits with beta-aminopropionitrile on blood clotting and fibrinolysis was studied.

The increase of clotting time of whole blood and recalcified plasma accompanied with the decrease of factor IX, XI and XIII level were observed. On the other hand the significant increase of fibrinogen content and soluble complexes of fibrin monomers level was found.

A deep inhibition of fibrinolytic activity of plasma was stated. The decrease of thromboplastic and fibrinolytic activity of saline extracts of some internal organs was also observed. The mechanism of above described changes and their significance in pathology are discussed.

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Referenzen

References
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