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J Neurol Surg B Skull Base 2018; 79(S 04): S316-S321
DOI: 10.1055/s-0038-1651522
WFSBS 2016
Georg Thieme Verlag KG Stuttgart · New York

Long-Term Outcomes of Patients with Squamous Cell Carcinoma of the Temporal Bone after Concomitant Chemoradiotherapy

Kiyoto Shiga
1   Department of Head and Neck Surgery, Iwate Medical University Hospital, Iwate Medical University, Morioka, Japan
,
Katsunori Katagiri
1   Department of Head and Neck Surgery, Iwate Medical University Hospital, Iwate Medical University, Morioka, Japan
,
Daisuke Saitoh
1   Department of Head and Neck Surgery, Iwate Medical University Hospital, Iwate Medical University, Morioka, Japan
,
Takenori Ogawa
2   Department of Otolaryngology–Head and Neck Surgery, Tohoku University Hospital, Tohoku University, Sendai, Japan
,
Kenjiro Higashi
2   Department of Otolaryngology–Head and Neck Surgery, Tohoku University Hospital, Tohoku University, Sendai, Japan
,
Hisanori Ariga
3   Department of Radiation Oncology, Iwate Medical University Hospital, Iwate Medical University, Morioka, Japan
› Author Affiliations
Further Information

Publication History

01 February 2018

03 April 2018

Publication Date:
14 May 2018 (online)

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Abstract

Objectives This article aims to clarify the long-term outcomes of patients with squamous cell carcinoma of the temporal bone who underwent concomitant chemoradiotherapy (CCRT).

Design and Setting The study design was a retrospective chart review.

Patients and Methods From December 2001 to June 2014, 23 patients with cancer of the temporal bone who were treated by CCRT at the Tohoku University Hospital and the Iwate Medical University Hospital were enrolled in this study. For advanced cancer of the temporal bone, a modified docetaxel, cisplatin, and 5-fluorouracil (TPF) regimen was used for CCRT. The long-term outcomes, including prognoses and late complications, were analyzed after CCRT of patients with cancers of the temporal bone.

Results The main long-term complications were stenosis of the external auditory canal and conductive hearing loss. No harmful late complications were observed in these patients. Disease-specific survival rates were 84.9% for all patients, 100% for patients of stage I, II, and III (n = 10), and 75.5% for patients of stage IV (n = 13) at 5 years.

Conclusions Our study showed that CCRT is an effective treatment choice for squamous cell carcinoma of the temporal bone. Furthermore, CCRT using the TPF regimen is a safe and effective initial treatment for patients with advanced cancers of the temporal bone.

Keywords

squamous cell carcinoma - external auditory canal - chemoradiotherapy - long-term prognosis - adverse events - complications
 

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