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DOI: 10.1055/s-0038-1651874
Platelet Aggregate Ratios – Standardization of Technique and Test Results in Patients with Myocardial Ischemia and Patients with Cerebrovascular Disease
Publication History
Received
31 January 1977
Accepted
15 June 1977
Publication Date:
04 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/197702/lookinside/thumbnails/10-1055-s-0038-1651874-1.jpg)
Summary
The technique for measuring platelet aggregate ratios described by Wu and Hoak (1974) was evaluated in normal subjects. The following had no influence upon the test result: age, sex, fasting versu the postprandial state, and the degree of stasis prior to drawing the sample. Variance within subjects was small compared to variance between subjects (0.0009 versus 0.0053, p < 0.01). Platelet aggregate ratios were then measured in 36 patients with coronary artery disease hospitalized with acute chest pain. Their mean platelet aggregate ratio of 0.86 was identical to the mean ratio for 47 normal subjects. Greater variability was found within patients (between samples) than within the normal subjects. This observation raises doubts about the significance of a single measurement of platelet aggregate ratio in such acutely ill patients. Mean platelet aggregate ratios measured daily did not differ over a 7-day period between 11 patients who developed a myocardial infarction and 10 patients who did not. A normal mean platelet ratio was also found on a single measurement from 30 patients with a history of completed stroke (0.87) and from 11 patients with a history of transient ischemic attacks (0.92).
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References
- 1 Dougherty J. H, McIntyre N, Weksler B. B. 1975 Assessment of platelet activation in relation to acute thrombotic events. Program. 18th Annual Meeting of the American Society of Hematology. Abstract #62, p. 67.
- 2 Dougherty Jr. J. H, Levy D, Weksler B. B. 1977; Platelet activation in acute cerebral ischaemia. Serial measurements of platelet function in cerebrovascular disease. Lancet I: 821.
- 3 Gjesdal K. 1976; Platelet function and plasma-free fatty acids during acute myocardial infarction and severe angina pectoris. Scandinavian Journal of Haematology 17: 205.
- 4 Haerem J. W. 1972; Sudden coronary death: platelet aggregates in intramyocardial arteries of man. Atherosclerosis 15: 199.
- 5 Haerem J. W. 1974; Platelet aggregates and mural microthrombi in the early stages of acute, fatal coronary disease. Thrombosis Research 5: 243.
- 6 Jørgenson L, Rowesll H. C, Hovig T, Glynn M. R, Mustard J. F. 1967; Platelet aggregation and myocardial infarction in swine. Laboratory Investigations 17: 616.
- 7 Maca R. D, Fry G. L, Hoak J. C. 1972; New method for detecting and quantitating circulating platelet aggregates. Microvascular Research 4: 453.
- 8 Schefler W. C. 1969. Statistics for the Biological Sciences. Addison-Wesley Publishing Co.; Menlo Park, Calif.:
- 9 Woodward R. H, Goldsmith P.L. 1964. Cumulative Sum Techniques. Mathematical and Statistical Techniques for Industry, Monograph #3. Edinburgh, published for Imperial Chemical Industries by Oliver and Boyd; Princeton, New Jersey: 1.
- 10 Wu K. K, Hoak J. C. 1974; A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency. Lancet II: 924.
- 11 Wu K. K, Hoak J. C. 1975; Increased platelet aggregates in patients with transient ischemic attacks. Stroke 6: 521.