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Thromb Haemost 1977; 38(04): 0742-0750
DOI: 10.1055/s-0038-1651895
Original Article
Schattauer GmbH

A) Coagulation Proteins and Inhibitors: Cold-Insoluble Globulin (Clg), a Circulating Cell Surface Protein

Michael W. Mosesson
1   Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, N.Y. 11203, U.S.A.
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Publication History

Publication Date:
04 July 2018 (online)

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Summary

The history of the discovery and characterization of the cold-insoluble globulin of plasma (Clg) is reviewed. Subsequent growth of knowledge relating to its structure and function in plasma, in tissues, and on cell surfaces is examined.

 

  • References

  • 1 Aronsen K.-F, Ekelund G, Kindmark C.-O, Laurell C.-B. 1972; Sequential changes of plasma proteins after surgical trauma. Scandinavian Journal of Clinical and Laboratory Investigation 29 (Suppl. 124) 127.
    CrossrefPubMedSearch in Google Scholar
  • 2 Bang N. U, Hansen M. S, Smith G. F, Mosesson M. W. 1973; Properties of soluble fibrin polymers encountered in thrombotic states. Thrombosis et Diathesis Haemorrhagica (Suppl. 56) 76.
    PubMedSearch in Google Scholar
  • 3 Blumberg P. M, Robbins P. W. 1975; Effect of proteases on activation of resting chick embryo fibroblasts and on cell surface proteins. Cell 6: 137.
    CrossrefPubMedSearch in Google Scholar
  • 4 Bray B. A, Hsu K. C, Wigger H. J, LeRoy E. C. 1975; Association of fibrinogen and microfibrils with trophoblast basement membrane. Connective Tissue Research 3: 55.
    CrossrefPubMedSearch in Google Scholar
  • 5 Chen A. B, Mosesson M. W, Solish G. I. 1976; Identification of the cold-insoluble globulin of plasma in amniotic fluid. American Journal of Obstetrics and Gynecology 125: 958.
    CrossrefPubMedSearch in Google Scholar
  • 6 Chen A. B, Mosesson M. W. 1977; An improved method for purification of the cold-insoluble globulin of human plasma (CIg). Analytical Biochemistry 79: 144.
    CrossrefPubMedSearch in Google Scholar
  • 7 Chen A. B, Amrani D. L, Mosesson M. W. 1977; Heterogeneity of the cold-insoluble globulin of human plasma (CIg), a circulating cell surface protein. Biochimica et Biophysica Acta 493: 310.
    CrossrefPubMedSearch in Google Scholar
  • 8 Chen L. B, Buchanan J. M. 1975; Mitogenic activity of blood components I. Thrombin and prothrombin. Proceedings of the National Academy of Sciences of the United States of America 72: 131.
    CrossrefPubMedSearch in Google Scholar
  • 9 Chen L. B. 1977; Alteration in cell-surface LETS protein during myogenesis. Cell 10: 393.
    CrossrefPubMedSearch in Google Scholar
  • 10 Chen L. B, Gallimore P. H, McDougall J. K. 1976; Correlation between tumor induction and the large external transformation sensitive protein on the cell surface. Proceedings of the National Academy of Sciences of the United States of America 73: 3570.
    CrossrefPubMedSearch in Google Scholar
  • 11 Chen L. B, Maitland N, Gallimore P. H, McDougall J. K. 1977; Detection of large external transformation sensitive protein on some epithelial cells. Experimental Cell Research 106: 39.
    CrossrefPubMedSearch in Google Scholar
  • 12 Cooper H. A, Wagner R. H, Mosesson M. W. 1974; The cold-insoluble globulin of plasma and its relationship to factor VIII. Journal of Laboratory and Clinical Medicine 84: 258.
    PubMedSearch in Google Scholar
  • 13 Dolfini E, Azzarone B, Pedullà D, Ottaviano E, deGaetano G, Donati M. B, Morasca L. 1976; Characterization of human fibroblasts from cancer patients: Loss of fibrin clot retractile activity after ‘in vitro’ spontaneous transformation. European Journal of Cancer 12: 823.
    PubMedSearch in Google Scholar
  • 14 Edsall J. T, Gilbert G. A, Scheraga H. A. 1955; The non-clotting component of the human plasma fraction 1–1 (“cold insoluble globulin”). Journal of the American Chemical Society 77: 157.
    CrossrefPubMedSearch in Google Scholar
  • 15 Foreman B, Ganrot P. O, Gennser G, Rannevik G. 1972; Plasma protein pattern in recurrent cholestasis of pregnancy. Scandinavian Journal of Clinical and Laboratory Investigation 29 (Suppl. 124) 89.
    CrossrefPubMedSearch in Google Scholar
  • 16 Gahmberg C. G, Kiehn D, Hakomori S. 1974; Changes in a surface-labelled galactoprotein and in glycolipid concentrations in cells transformed by a temperature-sensitive polyoma virus mutant. Nature 248: 413.
    CrossrefPubMedSearch in Google Scholar
  • 17 Ganrot P. O. 1972; Variation of the concentrations of some plasma proteins in normal adults, in pregnant women and in newborns. Scandinavian Journal of Clinical and Laboratory Investigation 29 (Suppl. 124) 83.
    CrossrefPubMedSearch in Google Scholar
  • 18 Hynes R. O. 1973; Alteration of cell-surface proteins by viral transformation and by proteolysis. Proceedings of the National Academy of Sciences of the United States of America 70: 3170.
    CrossrefPubMedSearch in Google Scholar
  • 19 Hynes R. O, Bye J. M. 1974; Density and cell cycle dependence of cell surface proteins in hamster fibroblasts. Cell 3: 113.
    CrossrefPubMedSearch in Google Scholar
  • 20 Hynes R. O, Humphries K. C. 1974; Characterization of the external proteins of hamster fibroblasts. Journal of Cell Biology 62: 438.
    CrossrefPubMedSearch in Google Scholar
  • 21 Hynes R. O. 1976; Cell surface proteins and malignant transformation. Biochemica et Biophysica Acta 458: 73.
    PubMedSearch in Google Scholar
  • 22 Hynes R. O, Destree A. 1977; Extensive disulfide bonding at the mammahan cell surface. Proceedings of the National Academy of Sciences of the United States of America 14: 2855.
    PubMedSearch in Google Scholar
  • 23 Jilek F, Hörmann H. 1977; Cold-insoluble globulin II. Plasminolysis of cold-insoluble globulin. Hoppe-Seyler’s Zeitschrift für Physiologische Chemie 358: 133.
    PubMedSearch in Google Scholar
  • 24 Johansson B. G, Kindmark C.-O, Trell E. Y, Wollheim F. A. 1972; Sequential changes of plasma proteins after myocardial infarction. Scandinavian Journal of Clinical and Laboratory Investigation 29 (Suppl. 124) 117.
    CrossrefPubMedSearch in Google Scholar
  • 25 Keski-Oja J, Mosher D. F, Vaheri A. 1977; Dimetric character of fibronectin, a major cell surface-associated glycoprotein. Biochemical and Biophysical Research Communications 74: 699.
    CrossrefPubMedSearch in Google Scholar
  • 26 Klebe R. J. 1974; Isolation of a cohagen-dependent cell attachment factor. Nature 250: 248.
    CrossrefPubMedSearch in Google Scholar
  • 27 Kuusela P, Ruoslahti E, Vaheri A. 1975; Polypeptides of a glycoprotein antigen (SF) present in serum and surface of normal but not of transformed chicken fibroblasts. Biochimica et Biophysica Acta 379: 295.
    CrossrefPubMedSearch in Google Scholar
  • 28 Laurell C.-B. 1972; Composition and variation of the gel electrophoretic fractions of plasma, cerebrospinal fluid and urine. Scandinavian Journal of Clinical and Laboratory Investigation 29 (Suppl. 124) 71.
    CrossrefPubMedSearch in Google Scholar
  • 29 Linder E, Vaheri A, Ruoslahti E, Wartiovaara J. 1975; Distribution of fibroblast surface antigen in the developing chick embryo. Journal of Experimental Medicine 142: 41.
    CrossrefPubMedSearch in Google Scholar
  • 30 Lospalluto J, Dorward B, Miller Jr. W, Ziff M. 1962; Cryoglobulinemia based on interaction between gamma macroglobulin and 7 S gamma globulin. American Journal of Medicine 32: 142.
    CrossrefPubMedSearch in Google Scholar
  • 31 Morrison P. R, Edsall J. T, Miller S. G. 1948; Preparation and properties of serum and plasma proteins XVIII. The separation of purified fibrinogen from fraction I of human plasma. Journal of the American Chemical Society 70: 3103.
    CrossrefPubMedSearch in Google Scholar
  • 32 Mosesson M. W, Colman R. W, Sherry S. 1968; Chronic intravascular coagulation syndrome: Report of a case with special studies of an associated plasma cryoprecipitate (“cryofibrinogen”). New England Journal of Medicine 278: 815.
    CrossrefPubMedSearch in Google Scholar
  • 33 Mosesson M. W, Umfleet R. A. 1970; The cold-insoluble globulin of human plasma I. Purification, primary characterization, and relationship to fibrinogen and other cold-insoluble fraction components. Journal of Biological Chemistry 245: 5728.
    PubMedSearch in Google Scholar
  • 34 Mosesson M. W, Chen A. B, Huseby R. M. 1975; The cold-insoluble globulin of human plasma: Studies of its essential structural features. Biochimica et biophysica acta 386: 509.
    CrossrefPubMedSearch in Google Scholar
  • 35 Mosher D. F. 1975; Cross-linking of cold-insoluble globulin by fibrin-stabilizing factor. Journal of Biological Chemistry 250: 6614.
    PubMedSearch in Google Scholar
  • 36 Mosher D. F. 1976; a Action of fibrin-stabilizing factor on cold-insoluble globulin and a2-macroglobulin in clotting plasma. Journal of Biological Chemistry 251: 1639.
    PubMedSearch in Google Scholar
  • 37 Mosher D. F. 1976; b Changes in plasma cold-insoluble globulin concentration during experimental rocky mountain spotted fever infection in rhesus monkeys. Thrombosis Research 9: 37.
    CrossrefPubMedSearch in Google Scholar
  • 38 Niewiarowski S, Regoeczi E, Mustard J. F. 1972; Adhesion of fibroblasts to polymerizing fibrin and retraction of fibrin induced by fibroblasts. Proceedings of the Society for Experimental Biology and Medicine 140: 199.
    PubMedSearch in Google Scholar
  • 39 Niewiarowski S, Goldstein S. 1976; Fibrin clot retraction by human skin fibroblasts. Effects of ADP and thrombin. Proceedings of the Society for Experimental Biology and Medicine 151: 253.
    PubMedSearch in Google Scholar
  • 40 Pearlstein E. 1976; Plasma membrane glycoprotein which mediates adhesion of fibroblasts to collagen. Nature 262: 497.
    CrossrefPubMedSearch in Google Scholar
  • 41 Pollara B. 1963. Studies on the nature of cryofibrinogens. (Thesis # 63–7948) University Microfilms, Inc.; Ann Arbor, Michigan.:
    Search in Google Scholar
  • 42 Ruoslahti E, Vaheri A, Kuusela P, Linder E. 1973; Fibroblast surface antigen: a new serum protein. Biochimica et Biophysica Acta 322: 352.
    CrossrefPubMedSearch in Google Scholar
  • 43 Ruoslahti E, Vaheri A. 1974; Novel human serum protein from fibroblast plasma membrane. Nature 248: 790.
    PubMedSearch in Google Scholar
  • 44 Ruoslahti E, Vaheri A. 1975; Interaction of soluble fibroblast surface antigen with fibrinogen and fibrin. Identity with cold insoluble globulin of human plasma. Journal of Experimental Medicine 141: 497.
    CrossrefPubMedSearch in Google Scholar
  • 45 Ruoslahti E, Vaheri A. 1976; Immunological interspecies cross reaction of fibroblast surface antigen (fibronectin). Immunochemistry 13: 639.
    CrossrefPubMedSearch in Google Scholar
  • 46 Shainoff J. R, Page I. H. 1972; Deposition of modified fibrinogen within the aortic intima. Atherosclerosis 16: 287.
    CrossrefPubMedSearch in Google Scholar
  • 47 Smith R. T. von Korff 1957; A heparin-precipitable fraction of human plasma. I. Isolation and characterization of the fraction. Journal of Clinical Investigation 36: 596.
    CrossrefPubMedSearch in Google Scholar
  • 48 Smith E. B, Slater R. S, Hunter J. A. 1973; Quantitative studies on fibrinogen and low-density lipoprotein in human aortic intima. Atherosclerosis 18: 479.
    CrossrefPubMedSearch in Google Scholar
  • 49 Stathakis N. E, Mosesson M. W. 1977; Interactions among heparin, cold-insoluble globulin, and fibrinogen in formation of the heparin précipitable fraction of plasma. Journal of Clinical Investigation 60: 855.
    CrossrefPubMedSearch in Google Scholar
  • 50 Stemberger A, Hörmann H. 1976; Affinity chromatography on immobilized fibrinogen and fibrin monomer. II. The behavior of cold-insoluble globulin. Hoppe-Seyler’s Zeitschrift für Physiologische Chemie 357: 1003.
    PubMedSearch in Google Scholar
  • 51 Vaheri A, Ruoslahti E. 1975; Fibroblast surface antigen produced but not retained by virus-transformed human cells. Journal of Experimental Medicine 142: 530.
    CrossrefPubMedSearch in Google Scholar
  • 52 Vaheri A, Ruoslahti E, Westerwark B, Ponten J. 1976; A common cell type specific surface antigen in cultured human glial cells and fibroblasts: loss in malignat cells. Journal of Experimental Medicine 143: 64.
    CrossrefPubMedSearch in Google Scholar
  • 53 Wartiovaara J, Stenman S, Vaheri A. 1976; Changes in expression of fibroblast surface antigen (SFA) during cytodifferentiation and heterokaryon formation. Differentiation 5: 85.
    CrossrefPubMedSearch in Google Scholar
  • 54 Yamada K. M, Weston J. A. 1974; Isolation of a major cell surface glycoprotein from fibroblasts. Proceedings of the National Academy of Sciences of the United States of America 71: 3492.
    CrossrefPubMedSearch in Google Scholar
  • 55 Yamada K. M, Yamada S. S, Pastan I. 1976; Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proceedings of the National Academy of Sciences of the United States of America 73: 1217.
    CrossrefPubMedSearch in Google Scholar