Download PDF
Thromb Haemost 1969; 21(01): 012-019
DOI: 10.1055/s-0038-1653504
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

Fibrinolytic and Renin Activity in Renal Vein Blood of Patients with Renovascular Hypertension

A Nowak
1   Illrd Clinic of Internal Diseases, Silesian Academy of Medicine, Katowice (Director: Prof. Dr. K. Gibinski) and the Roentgenologic Department of the Central Hospital for Coal Miners in Bytom (Head: Dr. Z. Suwalski)
,
F Kokot
1   Illrd Clinic of Internal Diseases, Silesian Academy of Medicine, Katowice (Director: Prof. Dr. K. Gibinski) and the Roentgenologic Department of the Central Hospital for Coal Miners in Bytom (Head: Dr. Z. Suwalski)
,
Z Czekała
1   Illrd Clinic of Internal Diseases, Silesian Academy of Medicine, Katowice (Director: Prof. Dr. K. Gibinski) and the Roentgenologic Department of the Central Hospital for Coal Miners in Bytom (Head: Dr. Z. Suwalski)
,
J Dosiak
1   Illrd Clinic of Internal Diseases, Silesian Academy of Medicine, Katowice (Director: Prof. Dr. K. Gibinski) and the Roentgenologic Department of the Central Hospital for Coal Miners in Bytom (Head: Dr. Z. Suwalski)
,
J Kuska
1   Illrd Clinic of Internal Diseases, Silesian Academy of Medicine, Katowice (Director: Prof. Dr. K. Gibinski) and the Roentgenologic Department of the Central Hospital for Coal Miners in Bytom (Head: Dr. Z. Suwalski)
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Also available at
    Permissions and Reprints

Summary

The fibrinolytic system has been studied in 20 patients with renovascular hypertension.

Renal and hepatic venous blood was drawn by selective cathetherisations, while peripheral blood was obtained from the inferior vena cava above the bifurcation. In all blood samples the euglobulin fibrinolysis, antiplasmin, plasminogen, fibrinogen, and plasma renin activity were determined.

Samples were taken at recumbency and after tilting to 80° for 30 min. In contradistinction to plasma renin activity no differences of the fibrinolytic activity between renal and peripheral venous blood even in that obtained from ischemic kidneys were proved.

No diminished secretion of plasminogen activator by ischemic kidneys in man was stated.

In the light of the data obtained the participation of fibrinolytic system in the pathogenesis of renovascular hypertension is doubtfal.

 

  • References

  • 1 Alkjaersig N, Fletcher A. P, Sherry S. e-aminocaproic acid: an inhibitor of plasminogen activator. J. biol. Chem 234: 832 1959;
    PubMedSearch in Google Scholar
  • 2 Brahman P, Astrup T. Increased fibrinolytic activity in venons blood from the kidney. Fed. Proc 24: 387 1965;
    PubMedSearch in Google Scholar
  • 3 Boomgaard J, Vreeken J, Bleyenberg A, Deggeller K. Studies on urokinase. Some physiological considerations concerning normal urokinase excretion. Clin. chim. Acta 13: 484 1966;
    PubMedSearch in Google Scholar
  • 4 Boucher R, Veyrat R, De Champlain J, Genest J. New procedures for measurement of human plasma angiotensin and renin activity levels. Canad. med. Ass. J 90: 194 1964;
    PubMedSearch in Google Scholar
  • 5 Buluk K, Bielewiec M. An investigation of the urokinase content in the urine of various animals and man. Pol. Arch. Med. wewnçt 32: 162 1962;
    PubMedSearch in Google Scholar
  • 6 Buluk K, Furman M. On the controlling function of the kidneys in fibrinolysis. Experientia (Basel) 18: 146 1962;
    CrossrefPubMedSearch in Google Scholar
  • 7 Buluk K, Malofiejew M. Otrzymywanie aktywatora fibrynolizy w nerce poza ustrojem (aktywator fibrynolizy w izolowanej nerce). Acta physiol, pol 14: 371 1963;
    PubMedSearch in Google Scholar
  • 8 Carriere S, Thornburn G. D, O’Morchoe G. G, Berger A. C. Intrarenal distribution of blood flow in dogs during haemorrhagic hypotension. Circ. Res 19: 167 1966;
    CrossrefPubMedSearch in Google Scholar
  • 9 Cohen E. I, Conn J. W, Rovner D. R. Postural augmentation of plasma renin activity and aldosterone excretion in normal people. J. clin. Invest 46: 418 1967;
    CrossrefPubMedSearch in Google Scholar
  • 10 Fletcher A. P, Biederman O, Moore D, Alkjaersig N, Sherry S. Abnormal plasminogen - plasmin system activity (Fibrinolysis) in patients with hepatis cirrhosis : Its cause and consequences. J. clin. Invest 43: 681 1964;
    CrossrefPubMedSearch in Google Scholar
  • 11 Gabryelewicz A, Worowski K, Prokopowicz J, Niawiarowski S. t, Poplawski A. Znaczenie ukladu fibrinolitycznego osocza w patogenezie nadcisnienia i podcisnienia tçtniczego u ludzi. Pol. Arch. Med. wewnçt 34: 161 1967;
    PubMedSearch in Google Scholar
  • 12 Gaczew E, Mutawicjew D. Prostoj i tocznoj metod opriedjelienia fibrynogena w krowi, Lab. Dielo 04: 3 1958;
    PubMedSearch in Google Scholar
  • 13 Hagan J. J, Ablondi F. D, DeRenzo E. C. Purification and biochemical properties of human plasminogen. J. biol. Chem 235: 1005 1960;
    PubMedSearch in Google Scholar
  • 14 Holemans R, Johnston J. S, Reddick R. L. Release of plasminogen activator by the isolated perfused dog kidney. Nature (Lond) 208: 291 1965;
    CrossrefPubMedSearch in Google Scholar
  • 15 Holemans R, Maun L. S, Cope G. Fibrinolytic activity of renal venous and arterial blood. Amer. J. med. Sei 254: 330 1967;
    CrossrefPubMedSearch in Google Scholar
  • 16 Holemans R, Tysinger M. F. Site of origin of increased fibrinolytic activity during venous occlusion. Proc. Soc. exp. Biol. (N. Y) 118: 488 1965;
    CrossrefPubMedSearch in Google Scholar
  • 17 von Kaulla K. N. Liver in regulation of fibrinolytic activity. Lancet I: 1046 1964;
    PubMedSearch in Google Scholar
  • 18 von Kaulla K. N. Chemistry of thrombolysis. Human fibrinolytic enzymes. C. C. Thomas Publ; Springfield: 1962
    Search in Google Scholar
  • 19 Kokot F, Kuska J, Czekala Z. b, Nowak A. Reninaktivität im Nierenvenenplasma bei Kranken mit renovasculärer Hypertonie. Z. ges. inn. Med 23: 340 1968;
    PubMedSearch in Google Scholar
  • 20 Kokot F, Kuska J, Czekala Z. b. Hepatic inactivation of renin in man. Enzymol. Biol. Clin. 1968 In press..
    PubMedSearch in Google Scholar
  • 21 Kowalski E, Kopec S, Niewiarowski S. An evaluation of the euglobulin method for the determination of fibrinolysis. J. clin. Path 12: 215 1959;
    CrossrefPubMedSearch in Google Scholar
  • 22 Kucinski C. h, Fletcher A. Immunologic distinction between human plasma plasminogen activator and human urokinase. Fed. Proc 25: 194 1966;
    PubMedSearch in Google Scholar
  • 23 Kwaan H. C. Tissue fibrinolytic activity studied by a histochemical method. Fed. Proc 25: 52 1966;
    PubMedSearch in Google Scholar
  • 24 Kwaan H. C, Lo R, McFadzean A. J. S. On the production of plasma fibrinolytic activity within veins. Clin. Sei 16: 241 1957;
    PubMedSearch in Google Scholar
  • 25 Kwaan H. C, Fisher S. Localisation of fibrinolytic activity in kidney tissues. Fed. Proc 24: 387 1965;
    PubMedSearch in Google Scholar
  • 26 McConnell D, Johnson J. G, Holemans R, Cohen L. A. Blood plasminogen activator: Mechanism of its release and lack of identity with urokinase. Fed. Proc 25: 194 1966;
    PubMedSearch in Google Scholar
  • 27 McConnell D, Johnston J. G, Young I, Holemans R. Localisation of plasminogen activator in kidney tissue. Lab. Invest 15: 980 1966;
    PubMedSearch in Google Scholar
  • 28 Mitchell P., Cope I. The estimation of plasminogen in human serum or plasma. Clin. chim. Acta 11: 414 1965;
    CrossrefPubMedSearch in Google Scholar
  • 29 Niewiarowski S, Prokopowicz J, Poplawski A, Worowski K. Inhibition of dog fibrinolytic system in experimental tubular necrosis of the kidney. Experientia (Basel) 20: 10 1964;
    CrossrefPubMedSearch in Google Scholar
  • 30 Nowak A, Zahorska-Markiewicz B. Aktywnosc urokinazy i fibrynoliza w chorobach nerek. Pol. Arch. Med. wewnçt 35: 653 1965;
    PubMedSearch in Google Scholar
  • 31 Oliver W. J, Brody S. L. Effect of prolongated hypoxia upon granularity of renal juxtaglomerular cells. Circ. Res 16: 83 1965;
    CrossrefPubMedSearch in Google Scholar
  • 32 Prokopowicz J, Worowski K, Poplawski A, Mysliwiec M, Niewiarowski S. t. Fibrinolytic system in the dog with experimental renal (Goltblatt) hypertension. Experientia (Basel) 23: 224 1967;
    CrossrefPubMedSearch in Google Scholar
  • 33 Prokopowicz J, Worowski K, Poplawski A, Gabryelewicz A, Niewiarowski S. Fibrinolytic system in patients with hypertensive cardiovascular disease. Thrombos. Diathes. haemorrh. (Stuttg) 17: 1 1967;
    PubMedSearch in Google Scholar
  • 34 Worowski K, Niewiarowski S, Prokopowicz J. Fibrinolysis and fibrinogen breakdown products (antithrombin VI) in renal venous blood (R.V.B.) in dog. Thrombos. Diathes. haemorrh. (Stuttg) 12: 87 1964;
    PubMedSearch in Google Scholar
  • 35 Worowski K, Poplawski A, Kochanska J, Niewiarowski S. t. Effect of kidney elimination on fibrinolysis and clotting factors in dog blood plasma. Bull. Acad. pol. Ser. Sei biol 13: 683 1965;
    PubMedSearch in Google Scholar