Inhibition of Platelet Adhesiveness and Aggregation by Benzyl Alcohol and Phenol

Summary

Two amphipathic alcohols, benzyl alcohol and phenol, have been found to diminish adhesiveness of platelets to glass beads and to impair adenosine diphosphate (ADP)-induced platelet aggregation, while ethanol and isopropanol, both completely water soluble, had no inhibitory effects. Comparatively, phenol is a more potent inhibitor than benzyl alcohol. It is suggested that the basis for their antiadhesive effect may be similar to that which underlies their local anesthetic properties.

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