Download PDF
Thromb Haemost 1971; 26(02): 315-324
DOI: 10.1055/s-0038-1653679
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Quantitative Determination of Intravascular Coagulation in Vivo in Various Organs in the Dog

Ch Busch
1   Department of Forensic Medicine, Institute of Pathology and Forensic Medicine and the Radiobiological Department, Gustaf Werner Institute, University of Uppsala, Uppsala, Sweden
,
H Lundqvist
1   Department of Forensic Medicine, Institute of Pathology and Forensic Medicine and the Radiobiological Department, Gustaf Werner Institute, University of Uppsala, Uppsala, Sweden
,
T Saldeen
1   Department of Forensic Medicine, Institute of Pathology and Forensic Medicine and the Radiobiological Department, Gustaf Werner Institute, University of Uppsala, Uppsala, Sweden
› Author AffiliationsThis investigation was supported by grants from the Swedish Medical Research Council (No B 71-40X-2035-05, B 72-40X-2035-06 and B 71-23X-782-06), the Torsten and Ragnar Söderberg Foundation and AB Pharmacia.
Further Information

Publication History

Publication Date:
28 June 2018 (online)

Also available at
    Permissions and Reprints

Summary

A technique for determination of intravascular coagulation in different organs by means of continuous external detection of 125I-fibrinogen in the dog is described.

It is suggested that this technique would be of value in human beings as a complement to the present, often unsatisfactory methods for determination of microembolism.

 

  • References

  • 1 Arfors K. E, Busch G, Jakobsson S, Lindquist O, Malmberg P, Rammer L, Saldeen T. Pulmonary Insufficiency following Intravenous Injection of Thrombin and AMCA (tranexamic acid) in the Dog. Acta chir. scand. (In press.)
    PubMedGoogle Scholar
  • 2 Blombäck B, Blombäck M. Purification of human and bovine fibrinogen. Arkiv Kemi 10: 415 1956;
    PubMedGoogle Scholar
  • 3 Busch G, Rammer L, Saldeen T. Quantitation of fibrin deposition and elimination in various organs of rats injected with labelled fibrinogen and albumin. (To be published).
    PubMedGoogle Scholar
  • 4 Clarkson A. R, McDonald M. K, Fuster V, Robson J. S, Gash J. D. Intravascular coagulation in acute ischaemic renal failure. Abstracts from VI Conference on Microcirculation. Central-Try kkeriet Offset, Aalborg. 1970
    PubMedGoogle Scholar
  • 5 McKay D. G. Disseminated Intravascular Coagulation. An Intermediary Mechnism of Disease. Hoeber Medical Division. Harper & Row, Publishers: New York; 1965
    Google Scholar
  • 6 Reba R. C, McAsee J. G, Wagner H. N. Radiomercury labelled chlormerodrin for in vivo uptake studies and scintillation scanning of unilateral renal lesions associated with hypertension. Medicine 42: 269 1963;
    CrossrefPubMedGoogle Scholar
  • 7 Rosa U, Scassellatti G. A, Pennis F. Labelling of human fibrinogen with 1311 by electrolytic iodination. Biochim. biophys. Acta (Amst) 86: 519 1964;
    CrossrefPubMedGoogle Scholar
  • 8 Saldeen T. Experimental investigation on fat embolism and intravascular coagulation. Acta path, microbiol. scand 66: 271 1966;
    PubMedGoogle Scholar
  • 9 Saldeen T. Quantitative determination of intravascular coagulation in the lungs of experimental animals. Scand. J. Haemat 06: 206 1969;
    PubMedGoogle Scholar
  • 10 Saldeen T, Busch C, Lindquist O, Rammer L. The Microembolism syndrome. Acta path, microbiol. scand. (In press.)
    PubMedGoogle Scholar