Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1970; 23(03): 449-454DOI: 10.1055/s-0038-1654071 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH Cholecystectomy in a Patient with Hageman Trait Authors Author Affiliations A Girolami 1 University of Padua Medical School, Institute of “Semeiotica Medica” (Director: Prof. M. Austoni), Padua A Maffei * 1 University of Padua Medical School, Institute of “Semeiotica Medica” (Director: Prof. M. Austoni), Padua A Brunetti 1 University of Padua Medical School, Institute of “Semeiotica Medica” (Director: Prof. M. Austoni), Padua M Lazzarin 1 University of Padua Medical School, Institute of “Semeiotica Medica” (Director: Prof. M. Austoni), Padua Recommend Article Abstract Buy Article(opens in new window) Summary The case of a patient with Hageman trait who underwent cholecystectomy for cholelithiasis is reported. The surgical procedure was uneventful; no abnormal bleeding was noted during and after the operation. The transfusion of 4 cm3/kg b.w. of contacted 3-day old normal plasma corrected completely the coagulation abnormality. The glass and the silicone clotting times were slightly shortened even 64 h after the transfusion. The survival time for the infused factor XII activity resulted to be 41 h. 6 days after the plasma infusion the factor XII level was 1 % of normal. The significance of these findings is discussed. Full Text References References 1 Biggs R, Sharp A. A, Margolis J, Hardisty R. M, Stewart B. J, Davidson W. M. Defects in the early stages of blood coagulation: a report of four cases. Brit. J. Haemat 4: 177 1958; 2 Bok J, Veitkamp J. J, Loeliger E. A. Moderate factor XII deficiency. Thrombos. Diathes. haemorrh. (Stuttg.) 13: 8 1965; 3 Botti R. E, Ratnoff O. D. Studies on the pathogenesis of thrombosis. 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