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Thromb Haemost 1960; 4(02): 244-252
DOI: 10.1055/s-0038-1654502
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Improvements in the Thrombin Generation Test

Preben Ollendorff
1   Biological Institute of the Carlsberg Foundation, Copenhagen, and the Old Peoples Towny Copenhagen, Denmark
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Publication History

Publication Date:
17 June 2018 (online)

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Summary

The influence of glass contact on the thrombin generation test was demonstrated and a modified method described.

Nearly all prothrombin had been converted to thrombin before the thrombin concentration reached its maximum.

 

  • References

  • (1) Astrup Tage, Müllertz S. The Fibrin Plate Method for Estimating Fibrinolytic Activity. Arch. Biodiem. Biophys. 40: 346 1952;
    PubMedGoogle Scholar
  • (2) Astrup Tage, Sjølin Knud-Erik. Defects in Blood Coagulation. Dan med Bull 4: 164-168 1957;
    PubMedGoogle Scholar
  • (3) Biggs Rosemary, Douglas A. S, Macfarlane R. G. The Initial Stages of Blood Coagulation. J. Physiol. 122: 538-553 1953;
    CrossrefPubMedGoogle Scholar
  • (4) Dybkær René. A Coagulometer” for the Thrombin Generation Test on Plasma. Thromb. Diath. haem. 3: 110-112 1959;
    PubMedGoogle Scholar
  • (5) Dybkær René, Geill Torben. The Thrombin Generation Test on Plasma. Methods and Variation. Acta haemat. (Basel) 21: 156-165 1959;
    CrossrefPubMedGoogle Scholar
  • (6) Geill Torben. Studies on Blood Coagulation in Old Age. Pulmonary Thrombosis and Embolism. in: Cirrhosis of the Liver. Experimentelle Alternsforschung, Symposium Basel, IV 4.—7. 1956. 267-269 Birkhäuser; Basel, Stuttgart: 1956
    Google Scholar
  • (7) Geill Torben. Studier over blodkoagulationen i seniet. Forekomst af lungeemboli og thrombose. Nord. Med. 58: 1586-1587 1957;
    PubMedGoogle Scholar
  • (8) Geill Torben. Studies on Blood Coagulation in Old. Age. Thrombin Formation Following Haematomas and Traumatic Injuries to the Tissue. Fourth Congress of the Int. Assoc, of Geront., Merano (Bolzano), Italy. July 14—19, 1957. 357-361 Merano: 1957
    Google Scholar
  • (9) Kesseler Karlheinz. Über die klinische Bedeutung des Thrombin-Bildungstests. Dtsdi med. Wschr. 84: 267-272 1959;
    PubMedGoogle Scholar
  • (10) Macfarlane R. G, Biggs Rosemary. A Thrombin Generation Test. The Application in Haemophilia and Thrombocytopenia. J. clin. Pathol. 6: 3-8 1953;
    CrossrefPubMedGoogle Scholar
  • (11) Margolis J. Glass Surface and Blood Coagulation. Nature 178: 805-806 1956;
    PubMedGoogle Scholar
  • (12) O’Brien J. R. Relation of Blood-Coagulation to Lipaemia. Lancet 269: 690-693 1955;
    PubMedGoogle Scholar
  • (13) Ollendorff Preben. Defects in and Variability of the Thromboplastic System in Horse Plasma. Thromb. Diath. haem.. 1959 In the press.
    PubMedGoogle Scholar
  • (14) Owren P. A, Aas K. The Control of Dicumarol Therapy and the Quantitative Determination of Prothrombin and Proconvertin. Scand. J. clin. Lab. Invest 3: 201-208 1951;
    CrossrefPubMedGoogle Scholar
  • (15) Pitney W. R. Mild Haemophilia — a Clinical and Laboratory Study. Aust Ann Med. 6: 44-52 1957;
    PubMedGoogle Scholar
  • (16) Pitney W. R, Dacie J. V. A Simple Method of Studying the Generation of Thrombin in Recalcified Plasma. Application in the Investigation of Haemophilia. J. clin Pathol. 6: 9-14 1953;
    CrossrefPubMedGoogle Scholar
  • (17) Poole J. C. F, Robinson D. S. Further Observations on the Effects of Ethanolamine Phosphatide on Plasma Coagulation. Quart. J. exp. Physiol 41: 295-300 1956;
    PubMedGoogle Scholar
  • (18) Quick Armand J, Epstein Ernst. Thromboplastic Activity in Human Blood. J. appi. Physiol. 4: 840-847 1952;
    PubMedGoogle Scholar
  • (19) Quick Armand J, Hussey Clara V, Epstein Ernst. Activation of Thromboplastin by Thrombin. Amer. J. Physiol. 174: 123-126 1953;
    PubMedGoogle Scholar
  • (20) Robinson D. S, Poole J. C. F. The Similar Effect of Chylomicra and Ethanolamine Phosphatide on the Generation of Thrombin During Coagulation. Quart. J. exp. Physiol. 41: 36-50 1956;
    PubMedGoogle Scholar
  • (21) Sjølin Knud-Erik. The Thrombin Generation Test in the Diagnosis of Classical Hemophilia and Christmas Disease. Scand. J. clin. Lab. Invest. 8: 138-144 1956;
    CrossrefPubMedGoogle Scholar
  • (22) Sjølin Knud-Erik. Deficiency of a Factor in the Plasma Thromboplastin System revealed by Freezing. Dan. med. Bull. 3: 222-223 1956;
    PubMedGoogle Scholar
  • (23) Sjølin Knud-Erik. Lack of Christmas Factor in Horse Plasma. Nature 178: 153 1956;
    PubMedGoogle Scholar
  • (24) Sjølin Knud-Erik. Deficiency of the Hageman Factor Demonstrated by the Thrombin Generation Test. Thromb. Diath. haem. 1: 153-157 1957;
    PubMedGoogle Scholar
  • (25) Sjølin Knud-Erik. The Hageman Trait in a Family with Haemorrhagic Diathesis. Acta genet. (Basel) 7: 541-548 1957;
    PubMedGoogle Scholar
  • (26) Sjølin Knud-Erik. Coagulation Defect in Horse Plasma. Proc. Soc. exp. Biol. (N. Y.) 94: 818-820 1957;
    CrossrefPubMedGoogle Scholar
  • (27) Sjølin Knud-Erik. Variations of the Coagulation Defect in Hemophilia. VII Congresso Della Societa Internationale Di Ematologia. Roma: 1958: 287.
    Google Scholar
  • (28) Sjølin Knud-Erik. Hemophilic Diseases in Denmark. Thesis. 1959 In the press.
    PubMedGoogle Scholar
  • (29) Waaler Bjarne A. Contact Activation in the Intrinsic Blood Clotting System. Scand. J. clin. Lab. Invest.. 11. Suppl, no. 37 1959
    PubMedGoogle Scholar