Canine Hemophilia

Summary

Hemophilia A is reported in a Shetland sheepdog. The history, clotting defects and clinical course were similar to that seen in human hemophilia. As far as we know, no evidence of hemophilia has been reported in this breed. Bleeding episodes could be controlled by fresh frozen plasma given either intravenously or intraperitoneally.

Due to the disability of the dog and his inability to reproduce, he was destroyed. However, 2 female litter mates remain. We plan to try to establish a colony of these animals for further study.

^* Supported by grants from the Eli Lilly Co., Indianapolis, Ind., and the Abbott Laboratories, North Chicago, Ill.

^* Part of this work carried out during the term of a Post-Doctoral Fellowship from the National Cancer Institute, U.S.P.H.S. (W.C.L.).

^* From the William Pepper Laboratory of Clinical Medicine and the Hematology Section of the Department of Medicine, School of Medicine, University of Pennsylvania, and the School of Veterinary Medicine, University of Pennsylvania, Philadelphia.

• References

• (1) Hutt F. B, Rickard C. G, Field R. A. Sex-linked hemophilia in dogs. J. Hered. 39: 1 1948;
• (2) Graham J. B, Buckwalter J. A, Hartley L. J, Brinkhous K. M. Canine Hemophilia: Observations in the course, the clotting anomaly and the effect of blood transfusion. J. exp. Med. 90: 97 1949;
• (3) Mustard J. F, Rowsell H. C, Robinson G. A, Roeksema T. D, Downie H. G. Canine Hemophilia B (Christmas Disease). Brit. J. Haemat. 6: 259 1960;
• (4) Lee R. I, White P. D. A clinical study of the coagulation time of blood. Amer J. med. Sei. 145: 495 1913;
• (5) Stefanini M, Dameshek W. The Hemorrhagic Disorders. Grune and Stratton; New York: 1955
• (6) Quick A. S. Hemorrhagic Diseases. Lea and Febiger; Philadelphia: 1957
• (7) Biggs R, Douglas A. S. The thromboplastin generation test. J clin Path 6: 23 1953;