Download PDF
Thromb Haemost 1963; 10(02): 267-277
DOI: 10.1055/s-0038-1654782
Originalarbeiten — Original Article — Travaux Originaux
Schattauer GmbH

The Biological Disappearance Rate of Prothrombin, Factors VII, IX and X from Plasma in Hypothyroidism, Hyperthyroidism, and During Fever

E. A Loeliger
1   Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, and the Thrombosis Service (Head: E. A. Loeliger, M.D.,), Leyden, The Netherlands
,
B van der Esch
1   Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, and the Thrombosis Service (Head: E. A. Loeliger, M.D.,), Leyden, The Netherlands
,
Mieke J Mattern
1   Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, and the Thrombosis Service (Head: E. A. Loeliger, M.D.,), Leyden, The Netherlands
,
H. C Hemker
1   Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, and the Thrombosis Service (Head: E. A. Loeliger, M.D.,), Leyden, The Netherlands
› Author Affiliations
Further Information

Publication History

Publication Date:
24 July 2018 (online)

Also available at
    Permissions and Reprints

Summary

The biological disappearance rate of coagulation factors II, VIT, IX and X from plasma is decreased in myxoedema and increased in thyreotoxicosis. In patients with elevated body temperatures, an increase of up to three times the normal rate was observed. The clinical implications of these findings are briefly discussed.

 

  • References

  • 1 Davies J. W. L, Ricketts C. R, Bull J. P. Studies of plasma protein metabolism. Part I: Albumin in burned and injured patients. Clin. Sci. 23: 411 1962;
    PubMedSearch in Google Scholar
  • 2 vander Esch B. Thesis. Leiden. 1963
    PubMedSearch in Google Scholar
  • 3 Hart ChH.. Personal communication. 1963
    PubMedSearch in Google Scholar
  • 4 Hensen A, Loeliger E. A. Antithrombin III, its metabolism and its function in blood coagulation. Thrombos. Diathes. haemorrh. (Stuttg.). 09. suppl. 1 1963
    PubMedSearch in Google Scholar
  • 5 Loeliger E. A, Hensen A. Substitution therapy in haemophilia B. Thrombos. Diathes. haemorrh. (Stuttg.) 06: 391 1961;
    PubMedSearch in Google Scholar
  • 6 Loeliger E. A, van der Esch B, Mattern M. J, den Bra-bander A. S. A. Behaviour of factors II, VII, IX, and X during long-term treatment with coumarin. Thrombos. Diathes. haemorrh. (Stuttg.) 09: 74 1963;
    PubMedSearch in Google Scholar
  • 7 Loeliger E. A. et al. In preparation.
    PubMed
  • 8 Nilsson I. M, Blombäck M, Ramgren O. Haemophilia in Sweden. VI. Treatment of haemophilia A with the human antihaemophilic factor preparation (fraction I—0). Acta med. scand. 171 suppl. 379, 61 1962;
    PubMedSearch in Google Scholar
  • 9 Owren P. A, Aas K. The control of dicoumarol therapy and the quantitative determination of prothrombin and proconvertin. Scand. J. clin. Lab. Invest. 03: 169 1951;
    CrossrefPubMedSearch in Google Scholar
  • 10 Quick A. J. The physiology and pathology of hemostasis. Henry Kimpton; London: 1951
    Search in Google Scholar