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Thromb Haemost 1964; 11(01): 195-203
DOI: 10.1055/s-0038-1654819
Originalarbeiten — Original Articles — Travaux Originaux
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A New Abnormality of Platelet Function

E. J. Walter Bowie
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota
,
John H. Thompson Jr
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota
,
Charles A Owen Jr
1   Mayo Clinic and Mayo Foundation Rochester, Minnesota
› Author AffiliationsThis investigation was supported in part by Research Grant H-5008 from the National Institutes of Health, Public Health Service.
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Publication History

Publication Date:
22 June 2018 (online)

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Summary

This report concerns seven patients with thrombopathy, one of whom, a patient with a moderately severe bleeding tendency, exhibited a type of platelet deficiency not previously recorded. There was indirect evidence of platelet insufficiency in the prothrombin consumption test, which was not substantiated by direct examination of platelet function in the thromboplastin generation test. Since no antiplatelet activity could be demonstrated in the plasma, we are proposing the existence of a plasmatic factor which is necessary for the normal function of platelets, a factor lacking in this patient’s plasma.

 

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