Haemophilia A with Apparently Autosomal Dominant Inheritance

A Hensen; M. J Mattern; E. A Loeliger

doi:10.1055/s-0038-1654873

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1965; 14(03/04): 341-345
DOI: 10.1055/s-0038-1654873

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Haemophilia A with Apparently Autosomal Dominant Inheritance

Evidence for a Second Autosomal Locus Involved in Factor VIII Production

A Hensen

¹Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, Leyden, The Netherlands

,

M. J Mattern

¹Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, Leyden, The Netherlands

,

E. A Loeliger

¹Haematology Section of the Department of Internal Medicine (Head: Prof. J. Mulder, M.D.), University Hospital, Leyden, The Netherlands

› Author Affiliations

Abstract

Summary

Haemophilia A with autosomal dominant transmission is presented. Von Willebrand’s disease could be excluded on the basis of normal bleeding times and a negative result from transfusion of haemophilic plasma into the propositus. Therefore, the existence of a third gene locus involved in factor VIII production must be seriously considered.

Full Text

References

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