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Thromb Haemost 1965; 14(03/04): 454-465
DOI: 10.1055/s-0038-1654882
Originalarbeiten — Original Articles — Travaux Originaux
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A Study of the Defect in Thromboplastin Generation Produced by Concentrated Normal Platelets

S Shaw
1   Department of Haematology, Charing Cross Hospital Medical School, London
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

This paper provides experimental evidence that high concentrations of normal platelets can produce a secondary deficiency of the serum factor IX when the tests are carried out under optimal conditions. The deficiency is due to absorption of factor IX by the platelets.

 

  • References

  • Abraham Uhitin O. N, Johnson S. A, Caldwell M. J. A study of the defects in the blood coagulation mechanisms in polycythaemia vera. Amer. J. clin. Path. 36: 7 1961;
    PubMedGoogle Scholar
  • Alfos L. G, Field E. O, Ledlie E. M. Clinical Studies with DF32P on the lifespan of platelets. Lancet II: 941 1959;
    PubMedGoogle Scholar
  • Benney W. E, Lewis FJW. Christmas Factor (IX) defect in a case of haemorrhagic thrombocythaemia. J. clin. Path. 12: 551 1959;
    CrossrefPubMedGoogle Scholar
  • Biggs R, Douglas A. S. The thromboplastin-generation test. J. clin. Path. 06: 23 1953;
    CrossrefPubMedGoogle Scholar
  • Denson KWE. The specific assay of Prower-Stuart Factor and Factor VII. Acta haemat. (Basel) 25: 105 1961;
    CrossrefPubMedGoogle Scholar
  • Friedman I. A, Dupee A. B, Robbins J. H, Higgins F. C. Coagulation defect in thrombocythaemia located in the serum and plasma. Clin. res. Proc. 04: 236 1956;
    PubMedGoogle Scholar
  • bGoudemand and Hutin. Thrombocythémie Essentielle (Relation d’un cas). Sang. 28: 267 1957;
    PubMedGoogle Scholar
  • Gunz F. W. Haemorrhagic thrombocythaemia. A critical review. Blood 15: 706 1960;
    PubMedGoogle Scholar
  • Hardisty R. M, Wolff H. H. Haemorrhagic thrombocythaemia: a clinical and laboratory study. Brit. J. Haemat. 01: 390 1955;
    CrossrefPubMedGoogle Scholar
  • Hicks N. D, Pitney W. R. A rapid screening test for disorders or thromboplastin generation. Brit. J. Haemat. 03: 227 1957;
    CrossrefPubMedGoogle Scholar
  • Hyun B. H, Dawson E. A, Custer R. P. Evaluation of thrombocythaemia by the thromboplastin-generation test. Amer. J. clin. Path. 29: 539 1958;
    PubMedGoogle Scholar
  • Lemaire A, Debray J. Combrisson-Lebolloch Étude clinique, cytologique et biologique d’un cas de thrombocythémie chronique avec anémie. Sang. 28: 273 1957;
    PubMedGoogle Scholar
  • Shaw S. Haemorrhagic thrombocythaemia. Two cases treated by radioactive phosphorus. Brit, med. J. J: 1437 1961;
    PubMedGoogle Scholar
  • Shaw S, Oliver RAM. Primary haemorrhagic thrombocythaemia. Proc. Roy. Soc. Med. 51: 768 1958;
    PubMedGoogle Scholar
  • Soulier Alagille D, Larrieu M. J. Physiopathologie des hémorragies au cours des hyper plaquethoses. Sang. 28: 277 1957;
    PubMedGoogle Scholar
  • Spaet T. H, Bauer S, Melamed S. Haemorrhagic thrombocythaemia. A blood coagulation disorder. Arch, intern. Med. 98: 377 1956;
    CrossrefPubMedGoogle Scholar
  • Stefanini M, Dameshek W. The Haemorrhagic Disorders. 296 Grüne and Stratton; 1955
    Google Scholar
  • Tubiana M, Boiron M. Le traitment des thrombocythémies par le phosphore radio-actif. Sang. 28: 291 1957;
    PubMedGoogle Scholar