Two Typical Hereditary Charts of Congenital Factor VII Deficiency

F. J Cleton; E. A Loeliger

doi:10.1055/s-0038-1654905

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1961; 05(01): 087-092
DOI: 10.1055/s-0038-1654905

Originalarbeiten – Original Article – Travaux Originaux

Schattauer GmbH

Two Typical Hereditary Charts of Congenital Factor VII Deficiency

F. J Cleton

¹Clinic for Internal Medicine (Director: Prof. Dr. J. Mulder) University Hospital, Leiden, Holland

,

E. A Loeliger

¹Clinic for Internal Medicine (Director: Prof. Dr. J. Mulder) University Hospital, Leiden, Holland

› Author Affiliations

Abstract

Summary

The inheritance of congenital factor VII deficiency was investigated in 2 unrelated families. Out of 68 individuals, 4 (3 proven and 1 highly probable) were found to have severe factor VII deficiency (<C 0.1% factor VII), and 29 appeared to be heterozygotes (30—60% factor VII). The coagulation defect is due to an autosomal gene of intermediate expression and complete penetrance. The recessive character of the haemorrhagic diathesis due to the homozygous state for the abnormal gene is clearly demonstrated.

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References

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