Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1963; 09(01): 113-119DOI: 10.1055/s-0038-1654965 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH The Prothrombin Consumption Time Test in Thrombocytopenia[*] Armand J Quick 1 Department of Biochemistry Marquette University School of Medicine Milwaukee, Wisconsin , Martha Geppert 1 Department of Biochemistry Marquette University School of Medicine Milwaukee, Wisconsin › Author Affiliations Recommend Article Abstract Buy Article Summary The serum from adult platelet-poor plasma has a residual prothrombin content nearly as high as that of the plasma when measured by either the prothrombin consumption test or the two-stage method of Ware and Seegers. Good agreement between the two methods is obtained when the prothrombin concentration is altered by such means as absorption with Ca3(PO4)2. The prothrombin consumption test is a simple but delicate measure of the function of platelets in the generation of intrinsic thromboplastin. Full Text References References 1 Bordet J. Recherches sur la coagulation du sang (sérozyme et prosérozyme). C. R. Soc. Biol. 82: 896 1919; 2 Brinkhous K. M. A study of the clotting defect in hemophilia: the delayed formation of thrombin. Amer. J. med. Sci. 198: 509 1939; 3 Chevallier P, Guillot M, Fiehrer A, Pasquier C. Sur le pouvoir coagulant du plasma et du sérum d’un hémophilie. Sem. hôp. Paris. 22: 1607 1946; 4 Quick A. J. Studies on the enigma of the hemostatic dysfunction of hemophilia. Amer. J. med. Sci. 214: 272 1947; 5 Ware A. G, Fahey S. L, Seegers W. H. Platelet extract, fibrin formation and interaction of purified prothrombin and thromboplastin. Amer. J. Physiol. 154: 140 1948; 6 Johnson S. A, Caldwell M. J, Monto R. W. The blood coagulation mechanisms in thrombocytopenic blood. Thrombos. Diathes. haemorrh. 01: 433 1957; 7 Quick A. J, Shanberge J, Stefanini M. The role of platelets in the coagulation of the blood. Amer. J. med. Sci. 217: 198 1949; 8 Quick A. J. Hemorrhagic Diseases. Lea & Febiger; Philadelphia: 1957 9 Ware A. G, Seegers W. H. Two-stage procedure for the quantitative determination of prothrombin concentration. Amer. J. clin. Path. 19: 471 1949; 10 Quick A. J, Stefanini M. The chemical state of the calcium reacting in the coagulation of blood. J. gen. Physiol. 32: 191 1948; 11 Quick A. J. The determinant of the prothrombin time in normal human plasma. Thrombos. Diathes. haemorrh. 02: 226 1958; 12 Quick A. J, Murat L. G, Hussey C. Y, Burgess G. F. The prothrombin in the newborn. Surg. Gynec. Obst. 95: 671 1952; 13 Biggs R, Douglas A. S. The thromboplastin generation test. J. clin. Path. 06: 23 1953; 14 Stefanini M. Names or numbers. J. Amer. med. Assoc. 180: 346 1962;
