Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1967; 18(01/02): 080-088DOI: 10.1055/s-0038-1655019 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH Ultrastructural Observations on Platelet Adhesion Reactions[*] III. Platelet Interaction with Collagen and Platelets R. B Erichson 1 Department of Hematology, Laboratory Division, Montefiore Hospital and Medical Center, New York , J. R Cintron 1 Department of Hematology, Laboratory Division, Montefiore Hospital and Medical Center, New York › Author Affiliations Recommend Article Abstract Buy Article Summary The interaction of platelets with collagen and with other platelets in collageninduced platelet aggregates has been studied with the electron microscope. The contours of aggregated platelets closely conformed to each other at a finite and regular distance, usually 200 to 300 Ångstroms. Structural conformity of platelets and collagen was less regular and occurred with a narrower separation. These findings are discussed in relation to observations of platelet interaction with fibrin and latex particles. Full Text References References 1 Zucker M. B. Platelet agglutination and vasoconstriction as factors in spontaneous hemo-stasis in normal, thrombocytopenic, heparinized and hypothrombinemic rats. Amer. J. Physiol. 148: 275 1947; 2 Kjaerheim A, Hovig T. The ultrastructure of hemostatic blood platelet plugs in rabbit mesenterium. Thrombos. Diathes. haemorrh. (Stuttg) 07: 1 1962; 3 French J. E, Macfarlane R. G, Sanders A. G. The structure of hemostatic plugs and experimental thrombi in small arteries. Brit. J. exp. Path. 45: 467 1964; 4 Dalton A. J. A chrome-osmium fixation for electron microscopy. Anat. Rec. 121: 281 1955; 5 Luft J. Improvements in epoxy resin embedding methods. J. biophys. biochem. Cytol. 09: 409 1959; 6 Hugues J, Lapierre G. M. Nouvelles recherces sur l’accolement des plaquettes aux fibers de collagene. Thrombos. Diathes. haemorrh. (Stuttg) 11: 327 1964; 7 Hovig T. Aggregation of rabbit blood platelets produced in vitro by saline “extract” of tendons. Thrombos. Diathes. haemorrh. (Stuttg) 09: 248 1963; 8 Spaet T. H, Zucker M. B. Mechanism of platelet plug formation and role of adenosine diphosphate. Amer. J. Physiol. 206: 1267 1964; 9 Spaet T. H, Erichson R. B. The vascular wall in the pathogenesis of thrombosis. In: Pathogenesis and Treatment of Thromboembolic Diseases. Koller F, Duckert F, Streuli F. 67 F.K. Schattauer-Verlag; Stuttgart: 1965 10 Zucker M. B, Borrelli J. Platelet clumping produced by connective tissue suspensions and by collagen. Proc. Soc. exp. Biol. (N. Y) 109: 779 1962; 11 Erichson R. B, Katz A. J, Cintron J. R. Ultrastructural observations of platelet adhesion reactions. 1. Platelet-fibrin interaction. Blood. (In Press.) 12 Hoenig E, Erichson R. B. Ultrastructural observations of platelet adhesion reactions. 11. Platelet interaction with latex particles in vivo. (In Preparation.) 13 Hovig T. The effects of calcium and magnesium on rabbit blood platelet aggregation in vitro. Thrombos. Diathes. haemorrh. (Stuttg) 12: 179 1964; 14 Shermer R. W, Mason R. G, Wagner R. H, Brinkhous K. M. Studies on thrombin-induced platelet agglutination. J. exp. Med. 114: 905 1961; 15 Movat H. Z, Weiser W. J, Glynn M. F, Mustard J. F. Platelet phagocytosis and aggregation. J. Cell Biol. 27: 531 1965; 16 Weiss L. The adhesion of cells. Int. Rev. Cytol. 09: 187 1960; 17 Hovig T. The ultrastructure of rabbit blood platelet aggregates. Thrombos. Diathes. haemorrh. (Stuttg) 08: 455 1962; 18 Johnson S. A, Balboa R. S, Peterson H. J, Buckley M. The ultrastructure of platelet participation in hemostasis. Thrombos. Diathes. haemorrh. (Stuttg) 13: 65 1965; 19 Weiss P. Cell contact. Int. Rev. Cytol. 07: 391 1958; 20 Curtis A. S. G. Cell contacts: Some physical considerations. Amer. Naturalist 94: 37 1960; 21 Pethica B. A. The physical chemistry of cell adhesion. Exp. Cell. Res., Suppl. 08: 123 1961; 22 Bennett H. S. Morphological aspects of extracellular polysaccharides. J. Histochem. Cytochem. 11: 14 1963;
