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Thromb Haemost 1964; 12(02): 382-390
DOI: 10.1055/s-0038-1655552
Originalarbeiten – Original Articles – Travaux Originaux
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Orally Induced Fibrinolysis. A Critical Assessment of Pineapple Protease

Christine Hawkey
1   Department of Haematology St. George’s Hospital and Medical School, London
,
Margaret Howell
1   Department of Haematology St. George’s Hospital and Medical School, London
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

1. An enzyme Bromelain derived from the stalk of the Hawaiian pineapple has been studied. It is shown to be proteolytic in vitro against casein and fibrin, the effect on fibrin being direct and not due to activation of the fibrinolytic system.

2. The enzyme is not inhibited by the antiplasmins present in human serum.

3. The enzyme has in vitro antithrombin activity.

4. Oral doses of up to 5 mg/Kg body weight of enteric coated capsules of the enzyme failed to produce any detectable proteolytic activity in the plasma of human recipients. A possible explanation for this is offered.

 

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