Arterio-Venous Differences in the Components of the Fibrinolytic Enzyme System^[*]

Summary

1. The concentration of the major components of the fibrinolytic enzyme system was compared in venous and arterial blood samples from male subjects.

2. The plasminogen activator concentration was higher in venous blood and the arterio-venous difference increased as its concentration rose, but the ratio of the arterial to venous level remained constant.

3. No arterio-venous difference was found for anti-urokinase activity, antiplasmin, plasminogen and fibrinogen.

4. It is concluded that venous blood determinations of the components of the fibrinolytic enzyme system reflect satisfactorily arterial blood levels.

• References

• 1 Alkjaersig N, Fletcher A. P, Sherry S. The mechanism of clot dissolution by plasmin. J. clin. Invest 38: 1086 1959;
• 2 Ghakrabarti R, Birks P. M, Fearnley G. R. Origin of blood fibrinolytic activity from veins and its bearing on the fate of venous thrombi. Lancet I: 1288 1963;
• 3 Clarke R. L, Orandi A, Cliffton E. E. Induction of fibrinolysis by venous obstruction. Angiology 11: 367 1960;
• 4 Fearnley G. R, Ferguson J. Arterio-venous differences in natural fibrinolysis. Lancet 11: 1040 1957;
• 5 Fletcher A. P, Biederman O, Moore D, Alkjaersig A, Sherry S. Abnormal plasminogen-plasmin system activity (fibrinolysis) in patients with hepatic cirrhosis: its cause and consequences. J. clin. Invest 43: 681 1964;
• 6 Naimi S, Goldstein R, Proger S. Studies of coagulation and fibrinolysis of the arterial and venous blood in normal subjects and patients with atherosclerosis. Circulation 27: 904 1963;
• 7 Nilsson I. M, Olow B. Fibrinolysis induced by streptokinase in man. Acta chir. scand 123: 247 1962;
• 8 Ratnojf O. D, Menzie G. A new method for the determination of fibrinogen in small samples of plasma. J. Lab. clin. Med 37: 316 1951;
• 9 Remmert L. F, Cohen P. Partial purification and properties of a proteolytic enzyme of human serum. J. biol. Chem 181: 431 1949;
• 10 Sherry S, Lindemeyer R. I, Fletcher A. P, Alkjaersig N. Studies on enhanced fibrinolytic activity in man. J. clin. Invest 38: 810 1959;
• 11 Tighe J. R, Swan H. T. Fibrinolysis and venous obstruction. Clin. Sci 25: 219 1963;
• 12 Todd A. S. Localisation of fibrinolytic activity in tissues. Brit. med. Bull 20: 210 1964;