The blood coagulation mechanisms in thrombocytopenic blood^[*)]

Summary

Thrombocytopenic serum supports a short prothrombin consumption time, however, the same serum contains as little prothrombin as normal serum. The prothrombin consumption test of thrombocytopenic serum can be prolonged by adsorption on BaCO₃ or reduced again by the addition of the sodium citrate eluate. The antihemophilic activity of thrombocytopenic blood disappears when the blood clots as in normal blood and autoprothrombin I is present in much smaller amounts than in normal serum. The authors suggest that a new factor, a possible derivative of prothrombin, is responsible for the short prothrombin consumption value in thrombocytopenic blood.

 

No conflict of interest has been declared by the author(s).

^*) The authors wish to extend their grateful thanks to Dr. J. Frederic Johnson, Department of Physiology and Pharmacology, College of Medicine, Wayne State University, Detroit, Michigan for determination of two-stage ac-globulin values in thrombocytopenic serum, and to Dr. H. O. Singher, Ortho Research Laboratories, Raritan, New Jersey.

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