Effects of Acute Stress on Thrombosis

Ohad S. Bentur; Galit Sarig; Benjamin Brenner; Giris Jacob

doi:10.1055/s-0038-1660853

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2018; 44(07): 662-668
DOI: 10.1055/s-0038-1660853

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effects of Acute Stress on Thrombosis

Ohad S. Bentur

¹Institute of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

,

Galit Sarig

²Hematology Laboratory, Rambam Health Care Campus, Haifa, Israel

³Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

,

Benjamin Brenner

³Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

⁴Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel

,

Giris Jacob

⁵Department of Internal Medicine, Faculty of Medicine, J. Recanati Autonomic Dysfunction Center, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

› Author Affiliations

Abstract

Stress, the nonspecific response to any demand for change, is an adaptive response of the human body to various stimulants. As such, stress-induced hypercoagulation may represent an adaptive response to bleeding. Numerous epidemiological studies have revealed that a correlation exists between stress and thrombotic risk and biochemically, links of the relationship between psychological stress and coagulation pathways have been made. The stress reaction is coupled with neurohormonal changes mediated mainly by the sympathetic neural system and the hypothalamic–pituitary–adrenal axis. Singling out the specific pathways affecting coagulation in this complex response is hampered by many confounders. The mediators of the stress reaction (neurotransmitters and hormones) can directly affect platelets and the coagulation cascade and indirectly affect hemostasis via changes in hemodynamics. In this review, the authors will delineate the distinct neurobiological mechanisms that govern the effects of stress on coagulation, and report their recent findings.

Keywords

stress - coagulation - sympathetic nervous system - cortisol

Full Text

References

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