Near-Infrared Imaging Using Intravenous Indocyanine Green at a Conventional Dose to Locate Pulmonary Metastases: A Pilot Study

Masatsugu Hamaji; Toyofumi Fengshi Chen-Yoshikawa; Manabu Minami; Hiroshi Date

doi:10.1055/s-0038-1675346

The Thoracic and Cardiovascular Surgeon, Table of Contents

Thorac Cardiovasc Surg 2019; 67(08): 688-691
DOI: 10.1055/s-0038-1675346

Short Communication

Georg Thieme Verlag KG Stuttgart · New York

Near-Infrared Imaging Using Intravenous Indocyanine Green at a Conventional Dose to Locate Pulmonary Metastases: A Pilot Study

Masatsugu Hamaji

¹Department of Thoracic Surgery, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan

,

Toyofumi Fengshi Chen-Yoshikawa

¹Department of Thoracic Surgery, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan

,

Manabu Minami

²Department of Clinical Innovative Medicine, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan

,

Hiroshi Date

¹Department of Thoracic Surgery, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan

› Author Affiliations

Abstract

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Abstract

Intravenous indocyanine green (ICG) has been reported to localize intra-abdominal metastatic lesions in several clinical trials. Our pilot study aimed to investigate the feasibility and safety of ICG fluorescence localization in pulmonary metastasectomy using a near-infrared fluorescence thoracoscope. Each patient received intravenous 0.25 or 0.5 mg/kg of ICG. The maximum diameter of the tumor on computed tomography ranged from 0.5 to 3.5 (median: 1.15) cm. Intravenous ICG injection localized pulmonary metastases in a portion (3 patients) of the enrolled patients. Our preliminary results provided us with important information to modify the study protocol.

Keywords

pulmonary metastasis - clinical trial - near-infrared

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References

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