Pneumologie 2019; 73(02): 110-111
DOI: 10.1055/s-0039-1678388
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Immunohistochemically Detectable Metallothionein Expression in Malignant Pleural Mesotheliomas is Strongly Associated with Early Failure to Platin-Based Chemotherapy

Jan Schmeller   *
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Fabian D. Mairinger   *
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Michael Wessolly
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Elena Mairinger
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Sabrina Borchert
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Jens Kollmeier
2   Department of Pneumology, Helios Klinikum Emil von Behring, Berlin, Germany
,
Thomas Hager
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Thomas Mairinger
3   Department of Pathology, Helios Klinikum Emil von Behring, Berlin, Germany
,
Daniel C. Christoph
4   Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
5   Department of Internistic Oncology, Kliniken Essen Mitte, Essen, Germany
,
Robert F. H. Walter
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
6   Ruhrlandklinik, West German Lung Centre, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Wilfried E. E. Eberhardt
4   Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
6   Ruhrlandklinik, West German Lung Centre, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Till Plönes
7   Department of Thoracic Surgery and Thoracical Endoscopy, Ruhrlandklinik, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Jeremias Wohlschlaeger
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
8   Department of Pathology, Diakonissenkrankenhaus Flensburg, Flensburg, Germany
,
Bharat Jasani
9   Department of Pathology, Targos Molecular Pathology GmbH, Kassel, Germany
,
Kurt Werner Schmid
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Agnes Bankfalvi
1   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Publikationsverlauf

Publikationsdatum:
15. Februar 2019 (online)

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    Background Malignant pleural mesothelioma (MPM) is an aggressive tumour arising from the pleura, leading to a dismal prognosis. Platin-analoga are the drug of choice for the treatment of MPM, resulting in a response rate of merely 6 to 16%. The known heavy metal detoxifying effect of metallothionein (MT) may be the reason for heavy metal drug resistance of MPM.
    Methods 105 patients were retrospectively analysed immunohistochemically for their MT expression levels. Survival analysis was done by Cox-regression (COXPH model).
    Results COXPH were done in a linear and logarithmic scale revealing a significant association between expression of MT and shortened overall survival (p = 0.0009; p = 0.0003). For progression-free survival, again a strongly reduced overall survival rate could be observed for MT expressing tumours (p = 0.0134; p = 0.0152).
    Conclusion Our results indicate a possible resistance to platin-based chemotherapy by expression of MPM. Both, overall survival and progression-free survival are negatively correlated to detectable MT expression in MPM.


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    * These authors contributed equally to the study.