Introduction:
Cisplatin is common drug for treatment of some malignant tumors. Hearing loss, tinnitus
and vertigo are very often side effects by oncology patients who are treated with
combinations with other drugs – Antibiotics, Analgetics, Other anticancer drugs, Cardiovascular
drugs, Neurologic drugs. Sensoneural Hearing loss – hight frecuency sounds -4000 –
8000 Hz/1/are commonly affected.
Material and methods:
We observed 34 patients/16 female and 18 male/who were treated with Cisplastin combinated
with other drugs. We tried to systemize the most common groups of drugs that increase
hearing loss in combination with Cisplatin 50 mg/m2 i.v. 1,8 day., Vinorelbin 25 mg/m2
i.v. 1,8,15 day
Results:
We recommend to discuss clinical strategy to prevent this side effects, when combinating
this therapy with other drugs. We constatated that Ototoxicity/60 db SNHL/increases
the side effects when Cisplatin is combined with other medicaments.
Conclusion:
Cisplatin is widely used anticancer drug which causes irreversible hearing loss/5/.
Doctors should be familiar with the common side effects of some anticancer drugs they
usually use with combination with others ototoxic dugs.
It is very important to discus treatment of Patients presenting for the first time
with an otologic symptoms.
