CC BY-NC-ND 4.0 · Laryngorhinootologie 2019; 98(S 02): S158
DOI: 10.1055/s-0039-1686542
Abstracts
Otology

vHIT as a screening method for detection of vestibular hypofunction after perinatal, systemic gentamicin therapy – preliminary results

A Wenzel
1   UMM Klinik f. Hals-Nasen-Ohrenheilkunde, Kopf-&Halschirurgie, Mannheim
,
A Kotzur
2   UMM, Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Mannheim
,
C Warken
2   UMM, Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Mannheim
,
N Rotter
2   UMM, Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Mannheim
,
R Hülse
2   UMM, Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Mannheim
› Institutsangaben
 
 

    Introduction:

    The vestibulotoxic effect of aminoglycosides, especially gentamicin, has already been identified. Nevertheless gentamicin is a guideline-appropriate and potent medication for perinatal sepsis. Therefore, the aim of the present study was to assess a potential vestibulotoxic effect from perinatal gentamicin therapy in infants using the video head impulse test (vHIT).

    Patients and methods:

    Vestibular function was assessed using vHIT to evaluate horizontal semicircular canal function in 17 children who perinatally underwent a five-day intravenous therapy with gentamicin. Outcome measures included gain and the occurrence of refixational saccades.

    Results:

    All of the tested children revealed a normal gain in vHIT. Moreover, pathologic catch-up saccades could not be identified.

    Conclusion:

    Perinatal intravenous gentamicin therapy does not seem to cause a permanent vestibulotoxic effect in children. Nevertheless, further research in a larger cohort is needed to detect a possible vestibulotoxic effect.


    #
    Priv.-Doz. Dr. med. Angela Wenzel
    UMM, Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie,
    Theodor-Kutzer-Ufer 1 – 3, 68167
    Mannheim

    Publikationsverlauf

    Publikationsdatum:
    23. April 2019 (online)

    © 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

    Georg Thieme Verlag KG
    Stuttgart · New York