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Synthesis 2020; 52(24): 3881-3890
DOI: 10.1055/s-0039-1690087
DOI: 10.1055/s-0039-1690087
paper
Electrophilic Amination with Anthranils through Thioamide-Assisted Cobalt(III)-Catalyzed C(sp3)–H Activation
This work was supported by the National Natural Science Foundation of China (Grant No. 21602083) and the Natural Science Foundation of Jiangsu Province (Grant No. BK20160160). We also thank the Fundamental Research Funds for the Central Universities (JUSRP51703A) and Soochow University.Further Information
Publication History
Received: 04 January 2020
Accepted after revision: 13 February 2020
Publication Date:
03 March 2020 (online)
‡ These authors contributed equally to this work.
Abstract
Cobalt(III)-catalyzed electrophilic amination of inert C(sp3)–H bonds of weakly coordinating thioamides with readily accessible anthranil derivatives was accomplished under mild conditions, with good functional group tolerance, thus providing various amino aldehydes and amino ketones. Moreover, our protocol with the versatile [Cp*Co(MeCN)3][SbF6]2 features excellent atom-economy and oxidant-free conditions, and allows facile late-stage functionalization.
Key words
C(sp3)–H activation - electrophilic amination - cobalt(III) catalysis - anthranils - thioamidesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690087.
- Supporting Information
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Recent reviews on C–H aminations:
Selected reviews:
Representative examples for Pd:
Representative examples for Rh:
Representative examples for Ir:
Representative examples for Ru:
Selected reviews:
Representative examples:
Recent examples: