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Synthesis 2019; 51(21): 3973-3980
DOI: 10.1055/s-0039-1690182
DOI: 10.1055/s-0039-1690182
paper
One-Step Synthesis of 1H-Imidazo[1,5-a]imidazole Scaffolds and Access to their Polyheterocycles
Further Information
Publication History
Received: 12 March 2019
Accepted after revision: 27 July 2019
Publication Date:
21 August 2019 (online)
Abstract
In this work, we continue our adventure in the chemistry of 5-5 tri-nitrogen bicycles. We disclose herein a one-step reaction to synthesize 1H-imidazo[1,5-a]imidazoles with different substituents introduced through the use of a wide range of aldehydes and isocyanides by using a Groebke–Blackburn–Bienaymé multicomponent reaction. The aim is to build a new library of 1H-imidazo[1,5-a]imidazole scaffolds. This bicycle was then modified to access new nitrogen-containing polycyclic compounds.
Key words1
imidazo[1,5-a]imidazole - polyheterocycles - Buchwald cyclization - MCRs - imidazo[5′,1′:2,3]imidazo[4,5-b]indoleSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690182.
- Supporting Information
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