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Synthesis 2020; 52(07): 1007-1014
DOI: 10.1055/s-0039-1690806
DOI: 10.1055/s-0039-1690806
feature
Copper/Silver Cocatalyzed Regioselective C5–H Functionalization of 8-Aminoquinoline Amides with 1,3-Dicarbonyl Compounds
Financial support from the Natural Science Foundation of Shandong Province, China (Grant No. ZR2016JL009) and the University of Jinan is greatly appreciated.Further Information
Publication History
Received: 18 December 2019
Accepted after revision: 12 January 2020
Publication Date:
03 February 2020 (online)
Abstract
A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.
Key words
copper - silver - 8-aminoquinoline amides - 1,3-dicarbonyl compounds - C5–H functionalizationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690806.
- Supporting Information
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