Synlett 2020; 31(05): 459-462
DOI: 10.1055/s-0039-1690825
letter
© Georg Thieme Verlag Stuttgart · New York

1,2-Dihydropyridazines as Versatile Synthetic Intermediates

Thomas K. Britten
a   Department of Chemistry, Lancaster University, Bailrigg, LA1 4YB, UK   Email: s.coote@lancaster.ac.uk
,
Paul D. Kemmitt
b   Medicinal Chemistry, Research and Early Development, Oncology R & D, AstraZeneca, Cambridge, CB10 1XL, UK
,
Nathan R. Halcovitch
a   Department of Chemistry, Lancaster University, Bailrigg, LA1 4YB, UK   Email: s.coote@lancaster.ac.uk
,
Susannah C. Coote  ∗
a   Department of Chemistry, Lancaster University, Bailrigg, LA1 4YB, UK   Email: s.coote@lancaster.ac.uk
› Author AffiliationsFunding from AstraZeneca [CASE Top-Up Award to T.K.B. (2015–2019)] is gratefully acknowledged.
Further Information

Publication History

Received: 29 December 2019

Accepted after revision: 28 January 2020

Publication Date:
13 February 2020 (online)

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Published as part of the Special Section 11th EuCheMS Organic Division Young Investigator Workshop

Abstract

The reactivity of 1,2-dihydropyridazines under various conditions is described, leading to the formation of a variety of products, including 2-aminopyrroles, phenylenediamines, and several novel heterocyclic motifs.

Key words

dihydropyridazines - heterocycles - pyrroles - diazetidines - phenylenediamines

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690825.
  • Supporting Information
 

  • References and Notes

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