Vincristine Neuropathy in Children: Squatting (Sitting Cross Legged) Predisposes Common Peroneal Nerves to Be More Severely Affected than Tibial Nerves

Roshan Koul; Saleem Saleh Naiha Al Harousi; Sousan AlNabhani; Amna AlFutaisi

doi:10.1055/s-0039-1697584

Journal of Pediatric Neurology, Inhaltsverzeichnis

Journal of Pediatric Neurology 2020; 18(04): 182-184
DOI: 10.1055/s-0039-1697584

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Vincristine Neuropathy in Children: Squatting (Sitting Cross Legged) Predisposes Common Peroneal Nerves to Be More Severely Affected than Tibial Nerves

Roshan Koul

¹Department of Child Health (Neurology), Sultan Qaboos University Hospital, College of Medicine and Health Sciences, Muscat, Oman

²Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India

,

Saleem Saleh Naiha Al Harousi

¹Department of Child Health (Neurology), Sultan Qaboos University Hospital, College of Medicine and Health Sciences, Muscat, Oman

,

Sousan AlNabhani

¹Department of Child Health (Neurology), Sultan Qaboos University Hospital, College of Medicine and Health Sciences, Muscat, Oman

,

Amna AlFutaisi

¹Department of Child Health (Neurology), Sultan Qaboos University Hospital, College of Medicine and Health Sciences, Muscat, Oman

› Institutsangaben

Abstract

Objective The main objective of this article was to evaluate vincristine neuropathy effect on common peroneal and tibial nerves.

Methods A retrospective study was conducted in children with vincristine neuropathy between August 2006 and January 2016 at Sultan Qaboos University Hospital.

Results Twenty-eight children (15 females and 13 males) were included in the study. The compound muscle action potential of common peroneal nerves was significantly reduced relative to the tibial nerves (p < 0.05)). There was no difference in latency and nerve conduction velocity between the two nerves.

Conclusion Children receiving vincristine demonstrate severe peroneal neuropathy compared with tibial nerves. We conclude that squatting posture effects peroneal nerves and postulate that the peroneal nerves are affected more due to the squatting posture. This squatting posture stretches the nerves that are already affected by the toxic effect of vincristine.

Keywords

vincristine neuropathy - squatting - children

Volltext

Referenzen

References
1 al Lamki Z, Wali YA, Shah WM, Zachariah M. Relapsed acute leukemia in children: Oman experience. Pediatr Hematol Oncol 2004; 21 (02) 167-173
2 Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. J Peripher Nerv Syst 2008; 13 (01) 27-46
3 Nazir HF, AlFutaisi A, Zacharia M. , et al. Vincristine-induced neuropathy in pediatric patients with acute lymphoblastic leukemia in Oman: frequent autonomic and more severe cranial nerve involvement. Pediatr Blood Cancer 2017; 64 (12) e26677
4 Kava M, Walsh P, Srinivas Jois R, Cole C, Lewis B, Nagarajan L. Clinical and Electrophysiological Characteristics of Vincristine Induced Peripheral Neuropathy in Children. JINCA 2017; 17 (75) 1-12
5 Jain P, Gulati S, Seth R, Bakhshi S, Toteja GS, Pandey RM. Vincristine-induced neuropathy in childhood ALL (acute lymphoblastic leukemia) survivors: prevalence and electrophysiological characteristics. J Child Neurol 2014; 29 (07) 932-937
6 Jordan MA. Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr Med Chem Anticancer Agents 2002; 2 (01) 1-17
7 Ramchandren S, Leonard M, Mody RJ. , et al. Peripheral neuropathy in survivors of childhood acute lymphoblastic leukemia. J Peripher Nerv Syst 2009; 14 (03) 184-189
8 van de Velde ME, Kaspers GL, Abbink FCH, Wilhelm AJ, Ket JCF, van den Berg MH. Vincristine-induced peripheral neuropathy in children with cancer: a systematic review. Crit Rev Oncol Hematol 2017; 114: 114-130
9 Toğrol E. Bilateral peroneal nerve palsy induced by prolonged squatting. Mil Med 2000; 165 (03) 240-242