RSS-Feed abonnieren
DOI: 10.1055/s-0039-3399964
Antispasmodic phenolic compounds isolated from Morus nigra root bark
Publikationsverlauf
Publikationsdatum:
20. Dezember 2019 (online)
Natural antispasmodic agents may have a potential for the treatment of asthma or gastrointestinal disorders including irritable bowel syndrome. Morus nigra has been valued as an antispasmodic traditional medicine but no related studies are available on its isolated constituents [1].
In this study, our aim was to investigate the antispasmodic potential of phenolic compounds of the root bark of M. nigra.
Seven compounds were isolated through the consecutive use of various preparative chromatographic techniques. These compounds were identified as morusin (1), kuwanon U (2), kuwanon E (3), moracin P (4), moracin O (5), albanol A (6), and albanol B (7). Their ex vivo antispasmodic activity was tested on isolated rat ileal and tracheal smooth muscles. Compound 2, 5 and 7 exerted strong activity on both models, while compound 3 (a methoxy analog of 2) was inactive. EC50 values and maximum effects for compounds 2 and 7 showed them equipotent with papaverin. Moracin O (5) exerted antispasmodic activity on ileal and tracheal muscles with EC50 values of 1.1 µM and 62 nM, respectively, and showed maximum effects on both muscles significantly higher than those of papavarine. Our findings suggest moracin O (5) as a new antispasmodic lead compound.
![](https://www.thieme-connect.de/media/plantamedica/201918/thumbnails/10.1055s-0039-3399964-f0001.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
#
Acknowledgments
The NKFIH, Hungary (K119770), the János Bolyai fellowship of the Hungarian Academy of Sciences, the UNKP-18-4 New National Excellence Program of the Ministry of Human Capacities, and the Kálmán Szász Prize are acknowledged.
-
References
- 1 Akhlaq A, Mehmood MH, Rehman A, Ashraf Z, Syed S, Bawany SA. etal. The Prokinetic, Laxative, and Antidiarrheal Effects of Morus nigra: Possible Muscarinic, Ca2+ Channel Blocking, and Antimuscarinic Mechanisms. Phytother Res 2016; 30: 1362-1376
-
References
- 1 Akhlaq A, Mehmood MH, Rehman A, Ashraf Z, Syed S, Bawany SA. etal. The Prokinetic, Laxative, and Antidiarrheal Effects of Morus nigra: Possible Muscarinic, Ca2+ Channel Blocking, and Antimuscarinic Mechanisms. Phytother Res 2016; 30: 1362-1376
![](https://www.thieme-connect.de/media/plantamedica/201918/thumbnails/10.1055s-0039-3399964-f0001.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)