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DOI: 10.1055/s-0039-3399965
Anti-staphylococcal activity of Myristica hypargyraea and Myristica inutilis from Samoa
Publikationsverlauf
Publikationsdatum:
20. Dezember 2019 (online)
Staphylococcus aureus is a human pathogen colonizing especially skin and respiratory tract. This bacteria has a harmful potential to cause a variety of community and hospital-acquired infections. Over the years, S. aureus strains resistant to commonly used antibiotics have been reported, which complicates the staphylococcal infections’ treatment [1]. Various plant-derived products, such as Melaleuca alternifolia essential oil, are used for elimination of S. aureus in clinical practice [2]. Therefore, plant compounds and their mixtures (e.g. extracts) are still perspective materials for the development of new anti-staphylococcal agents. Since the antimicrobial properties of some Myristica sp. have already been reported [3], we decided to evaluate growth-inhibitory effects of seed and aril hexane extracts from two Samoan indigenous plant species Myristica hypargyraea A.Gray and Myristica inutilis Rich ex A.Gray, against twelve S. aureus strains including antibiotic-resistant forms using the broth microdilution method [4].
In this study, all plant extracts tested showed a certain degree of anti-staphylococcal effect with minimum inhibitory concentrations (MICs) ranging from 8 to 1,024 µg/mL. The aril extract of M. hypargyraea possessed the highest antibacterial activity against S. aureus ATCC 33591 and three clinical isolates with a MIC value of 8 µg/mL.
Our results suggest potent antimicrobial properties of seed and aril extracts from M. hypargyraea and M. inutilis that could be used by the pharmaceutical industry for the treatment of skin and respiratory infections caused by S. aureus. However, further research focused on chemical analysis, cytotoxic effects and in vivo evaluation is necessary to be carried out.
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Acknowledgments
This research was financially supported by the Czech University of Life Sciences Prague (projects IGA 20195003)
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References
- 1 Oliveira D, Borges A, Simoes M. Staphylococcus aureus toxins and their molecular activity in infectious diseases. Toxins 2018; 10 (06) : 252
- 2 Kokoska L, Kloucek P, Leuner O, Novy P. Plant-derived products as antibacterial and antifungal agents in human health care. Curr Med Chem 2019; 26: 1
- 3 Narasimhan B, Dhake AS. Antibacterial principles from Myristica fragrans seeds. J Med Food 2006; 9 (03) : 395
- 4 Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. CLSI 2015 Twenty-fifth informational supplement M100-S25. Wayne (PA).
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References
- 1 Oliveira D, Borges A, Simoes M. Staphylococcus aureus toxins and their molecular activity in infectious diseases. Toxins 2018; 10 (06) : 252
- 2 Kokoska L, Kloucek P, Leuner O, Novy P. Plant-derived products as antibacterial and antifungal agents in human health care. Curr Med Chem 2019; 26: 1
- 3 Narasimhan B, Dhake AS. Antibacterial principles from Myristica fragrans seeds. J Med Food 2006; 9 (03) : 395
- 4 Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. CLSI 2015 Twenty-fifth informational supplement M100-S25. Wayne (PA).